Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients?
PURPOSE: Obesity is associated with cardiovascular disease, affecting large arteries and the microcirculation. Waist circumference and body mass index are routinely employed as measures for assessing obesity-related health risk, whereas waist-to-hip ratio is not. We aimed to investigate the associat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2006-02-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100010&tlng=en |
| _version_ | 1811329300653146112 |
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| author | Nivaldo Ribeiro Villela Luiz Guilherme Kraemer Aguiar Luciana Bahia Daniel Bottino Eliete Bouskela |
| author_facet | Nivaldo Ribeiro Villela Luiz Guilherme Kraemer Aguiar Luciana Bahia Daniel Bottino Eliete Bouskela |
| author_sort | Nivaldo Ribeiro Villela |
| collection | DOAJ |
| description | PURPOSE: Obesity is associated with cardiovascular disease, affecting large arteries and the microcirculation. Waist circumference and body mass index are routinely employed as measures for assessing obesity-related health risk, whereas waist-to-hip ratio is not. We aimed to investigate the association between brachial vascular reactivity and body mass index, waist circumference, and waist-to-hip ratio. METHODS: Eighty-five volunteers (21 men/66 women), aged between 20 and 55 years, underwent determination of waist circumference, body mass index, waist-to-hip ratio, and endothelial function by venous occlusion plethysmography. Forearm blood flow was measured in response to intrabrachial artery infusions of 3 different concentrations of endothelium-dependent (acetylcholine 7.5, 15, and 30 mg/min) and endothelium-independent (sodium nitroprusside 2, 4, and 8 mg/min) vasodilators. RESULTS: There was an inverse correlation of body mass index and waist circumference with forearm blood flow increments after acetylcholine and sodium nitroprusside infusions, while waist-to-hip ratio showed an inverse correlation with forearm blood flow increments only after acetylcholine. When subjects older than 40 years (n = 25) were excluded from the analysis, the inverse correlation of body mass index with forearm blood flow increments after acetylcholine infusion no longer existed, while waist circumference and waist-to-hip ratio showed the same results observed before. CONCLUSION: The waist-to-hip ratio is probably a better estimator of endothelial dysfunction and possibly of cardiovascular risk than body mass index. These findings underscore the importance of routinely collecting hip circumference as an obesity index and risk estimator. |
| first_indexed | 2024-04-13T15:41:23Z |
| format | Article |
| id | doaj.art-e5f9aba14981480d9ae436f7b64401ef |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T15:41:23Z |
| publishDate | 2006-02-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-e5f9aba14981480d9ae436f7b64401ef2022-12-22T02:41:09ZengElsevier EspañaClinics1980-53222006-02-01611535710.1590/S1807-59322006000100010Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients?Nivaldo Ribeiro Villela0Luiz Guilherme Kraemer Aguiar1Luciana Bahia2Daniel Bottino3Eliete Bouskela4Universidade do Estado do Rio de JaneiroUniversidade do Estado do Rio de JaneiroUniversidade do Estado do Rio de JaneiroUniversidade do Estado do Rio de JaneiroUniversidade do Estado do Rio de JaneiroPURPOSE: Obesity is associated with cardiovascular disease, affecting large arteries and the microcirculation. Waist circumference and body mass index are routinely employed as measures for assessing obesity-related health risk, whereas waist-to-hip ratio is not. We aimed to investigate the association between brachial vascular reactivity and body mass index, waist circumference, and waist-to-hip ratio. METHODS: Eighty-five volunteers (21 men/66 women), aged between 20 and 55 years, underwent determination of waist circumference, body mass index, waist-to-hip ratio, and endothelial function by venous occlusion plethysmography. Forearm blood flow was measured in response to intrabrachial artery infusions of 3 different concentrations of endothelium-dependent (acetylcholine 7.5, 15, and 30 mg/min) and endothelium-independent (sodium nitroprusside 2, 4, and 8 mg/min) vasodilators. RESULTS: There was an inverse correlation of body mass index and waist circumference with forearm blood flow increments after acetylcholine and sodium nitroprusside infusions, while waist-to-hip ratio showed an inverse correlation with forearm blood flow increments only after acetylcholine. When subjects older than 40 years (n = 25) were excluded from the analysis, the inverse correlation of body mass index with forearm blood flow increments after acetylcholine infusion no longer existed, while waist circumference and waist-to-hip ratio showed the same results observed before. CONCLUSION: The waist-to-hip ratio is probably a better estimator of endothelial dysfunction and possibly of cardiovascular risk than body mass index. These findings underscore the importance of routinely collecting hip circumference as an obesity index and risk estimator.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100010&tlng=enEndotheliumVascular ReactivityWaist-to-Hip RatioBody Mass IndexWaist Circumference |
| spellingShingle | Nivaldo Ribeiro Villela Luiz Guilherme Kraemer Aguiar Luciana Bahia Daniel Bottino Eliete Bouskela Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? Clinics Endothelium Vascular Reactivity Waist-to-Hip Ratio Body Mass Index Waist Circumference |
| title | Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? |
| title_full | Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? |
| title_fullStr | Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? |
| title_full_unstemmed | Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? |
| title_short | Does endothelial dysfunction correlate better with waist-to-hip ratio than with body mass index or waist circumference among obese patients? |
| title_sort | does endothelial dysfunction correlate better with waist to hip ratio than with body mass index or waist circumference among obese patients |
| topic | Endothelium Vascular Reactivity Waist-to-Hip Ratio Body Mass Index Waist Circumference |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000100010&tlng=en |
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