Derepression may masquerade as activation in ligand-gated ion channels
Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36770-z |
| _version_ | 1797850002236637184 |
|---|---|
| author | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta |
| author_facet | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta |
| author_sort | Christian J. G. Tessier |
| collection | DOAJ |
| description | Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism. |
| first_indexed | 2024-04-09T18:53:18Z |
| format | Article |
| id | doaj.art-e5fa9addcd8a49da8c921ad38b2f143f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:53:18Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e5fa9addcd8a49da8c921ad38b2f143f2023-04-09T11:22:07ZengNature PortfolioNature Communications2041-17232023-04-011411810.1038/s41467-023-36770-zDerepression may masquerade as activation in ligand-gated ion channelsChristian J. G. Tessier0Johnathon R. Emlaw1Raymond M. Sturgeon2Corrie J. B. daCosta3Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaDepartment of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of OttawaLigand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.https://doi.org/10.1038/s41467-023-36770-z |
| spellingShingle | Christian J. G. Tessier Johnathon R. Emlaw Raymond M. Sturgeon Corrie J. B. daCosta Derepression may masquerade as activation in ligand-gated ion channels Nature Communications |
| title | Derepression may masquerade as activation in ligand-gated ion channels |
| title_full | Derepression may masquerade as activation in ligand-gated ion channels |
| title_fullStr | Derepression may masquerade as activation in ligand-gated ion channels |
| title_full_unstemmed | Derepression may masquerade as activation in ligand-gated ion channels |
| title_short | Derepression may masquerade as activation in ligand-gated ion channels |
| title_sort | derepression may masquerade as activation in ligand gated ion channels |
| url | https://doi.org/10.1038/s41467-023-36770-z |
| work_keys_str_mv | AT christianjgtessier derepressionmaymasqueradeasactivationinligandgatedionchannels AT johnathonremlaw derepressionmaymasqueradeasactivationinligandgatedionchannels AT raymondmsturgeon derepressionmaymasqueradeasactivationinligandgatedionchannels AT corriejbdacosta derepressionmaymasqueradeasactivationinligandgatedionchannels |