Derepression may masquerade as activation in ligand-gated ion channels

Derepression may masquerade as activation in ligand-gated ion channels

Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.

Bibliographic Details
Main Authors:	Christian J. G. Tessier, Johnathon R. Emlaw, Raymond M. Sturgeon, Corrie J. B. daCosta
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-36770-z

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