Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i>
Parkinson’s disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to impr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/12/5/758 |
| _version_ | 1797474337124515840 |
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| author | Arvie Camille V. de Guzman Md. Abdur Razzak Joong Hee Cho Ji Yi Kim Shin Sik Choi |
| author_facet | Arvie Camille V. de Guzman Md. Abdur Razzak Joong Hee Cho Ji Yi Kim Shin Sik Choi |
| author_sort | Arvie Camille V. de Guzman |
| collection | DOAJ |
| description | Parkinson’s disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to improving its aqueous solubility and bioavailability. The curcumin-loaded HSA nanoparticles were acquired in the particle size and at the zeta potential of 200 nm and −10 mV, respectively. The curcumin-loaded human serum albumin nanoparticles ameliorated Parkinson’s disease features in the <i>C. elegans</i> model, including body movement, basal slowing response, and the degeneration of dopaminergic neurons. These results suggest that curcumin nanoparticles have potential as a medicinal nanomaterial for preventing the progression of Parkinson’s disease. |
| first_indexed | 2024-03-09T20:28:37Z |
| format | Article |
| id | doaj.art-e5fb6d76b4104da0a295b92776657094 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T20:28:37Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e5fb6d76b4104da0a295b927766570942023-11-23T23:29:42ZengMDPI AGNanomaterials2079-49912022-02-0112575810.3390/nano12050758Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i>Arvie Camille V. de Guzman0Md. Abdur Razzak1Joong Hee Cho2Ji Yi Kim3Shin Sik Choi4The Natural Science Research Institute, Department of Food and Nutrition, Myongji University, Yongin 17058, KoreaThe Natural Science Research Institute, Department of Food and Nutrition, Myongji University, Yongin 17058, KoreaThe Natural Science Research Institute, Department of Food and Nutrition, Myongji University, Yongin 17058, KoreaThe Natural Science Research Institute, Department of Food and Nutrition, Myongji University, Yongin 17058, KoreaThe Natural Science Research Institute, Department of Food and Nutrition, Myongji University, Yongin 17058, KoreaParkinson’s disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to improving its aqueous solubility and bioavailability. The curcumin-loaded HSA nanoparticles were acquired in the particle size and at the zeta potential of 200 nm and −10 mV, respectively. The curcumin-loaded human serum albumin nanoparticles ameliorated Parkinson’s disease features in the <i>C. elegans</i> model, including body movement, basal slowing response, and the degeneration of dopaminergic neurons. These results suggest that curcumin nanoparticles have potential as a medicinal nanomaterial for preventing the progression of Parkinson’s disease.https://www.mdpi.com/2079-4991/12/5/758curcuminhuman serum albuminParkinson’s diseasenanoparticledopaminergic neuron |
| spellingShingle | Arvie Camille V. de Guzman Md. Abdur Razzak Joong Hee Cho Ji Yi Kim Shin Sik Choi Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> Nanomaterials curcumin human serum albumin Parkinson’s disease nanoparticle dopaminergic neuron |
| title | Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> |
| title_full | Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> |
| title_fullStr | Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> |
| title_full_unstemmed | Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> |
| title_short | Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in <i>C. elegans</i> |
| title_sort | curcumin loaded human serum albumin nanoparticles prevent parkinson s disease like symptoms in i c elegans i |
| topic | curcumin human serum albumin Parkinson’s disease nanoparticle dopaminergic neuron |
| url | https://www.mdpi.com/2079-4991/12/5/758 |
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