The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis
This study aimed to evaluate the role of post-mastectomy radiotherapy (PMRT) in T1-2N1 breast cancer. Between 2006 and 2014, a total of 504 patients with T1-2N1 breast cancer were analyzed. PMRT was administered to 71 patients, and 1:2 propensity score matching (PSM) was performed between the PMRT a...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/22/5473 |
| _version_ | 1797459873338753024 |
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| author | Kangpyo Kim Won Park Haeyoung Kim Won Kyung Cho Nalee Kim Seok Jin Nam Seok Won Kim Jeong Eon Lee Jonghan Yu Byung Joo Chae Se Kyung Lee Jai Min Ryu |
| author_facet | Kangpyo Kim Won Park Haeyoung Kim Won Kyung Cho Nalee Kim Seok Jin Nam Seok Won Kim Jeong Eon Lee Jonghan Yu Byung Joo Chae Se Kyung Lee Jai Min Ryu |
| author_sort | Kangpyo Kim |
| collection | DOAJ |
| description | This study aimed to evaluate the role of post-mastectomy radiotherapy (PMRT) in T1-2N1 breast cancer. Between 2006 and 2014, a total of 504 patients with T1-2N1 breast cancer were analyzed. PMRT was administered to 71 patients, and 1:2 propensity score matching (PSM) was performed between the PMRT and non-PMRT groups. Loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates were compared according to PMRT status. Thirteen and one loco-regional recurrences were observed in the PMRT and non-PMRT groups, respectively. Before PSM, the 8-year LRC, DFS, and OS rates in the non-PMRT and PMRT groups were 98.5% and 96.5% (<i>p</i> = 0.426), 89.7% and 91.2% (<i>p</i> = 0.700), and 91.5% and 92.1% (<i>p</i> = 0.679), respectively. Corresponding rates were 95.6% and 96.5% (<i>p</i> = 0.365), 84.1% and 91.2% (<i>p</i> = 0.185), and 88.4% and 92.1% (<i>p</i> = 0.276), respectively, after PSM. Multivariate analysis showed that three lymph node metastases were prognostic for LRC and DFS rates and LVI for OS rate. Arm lymphedema developed in 32.4% of patients who received PMRT, which was significantly higher than the non-PMRT group (<i>p</i> < 0.001). Contributions of PMRT for improvement of treatments outcomes in T1-2N1 breast cancer patients were not evident, while the incidence of arm lymphedema significantly increased after PMRT. Further prospective trials are required to re-evaluate the role of PMRT. |
| first_indexed | 2024-03-09T16:57:10Z |
| format | Article |
| id | doaj.art-e5fb8391a7a5466ca39747cb9b2f4596 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T16:57:10Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e5fb8391a7a5466ca39747cb9b2f45962023-11-24T14:34:41ZengMDPI AGCancers2072-66942023-11-011522547310.3390/cancers15225473The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched AnalysisKangpyo Kim0Won Park1Haeyoung Kim2Won Kyung Cho3Nalee Kim4Seok Jin Nam5Seok Won Kim6Jeong Eon Lee7Jonghan Yu8Byung Joo Chae9Se Kyung Lee10Jai Min Ryu11Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDivision of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaThis study aimed to evaluate the role of post-mastectomy radiotherapy (PMRT) in T1-2N1 breast cancer. Between 2006 and 2014, a total of 504 patients with T1-2N1 breast cancer were analyzed. PMRT was administered to 71 patients, and 1:2 propensity score matching (PSM) was performed between the PMRT and non-PMRT groups. Loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates were compared according to PMRT status. Thirteen and one loco-regional recurrences were observed in the PMRT and non-PMRT groups, respectively. Before PSM, the 8-year LRC, DFS, and OS rates in the non-PMRT and PMRT groups were 98.5% and 96.5% (<i>p</i> = 0.426), 89.7% and 91.2% (<i>p</i> = 0.700), and 91.5% and 92.1% (<i>p</i> = 0.679), respectively. Corresponding rates were 95.6% and 96.5% (<i>p</i> = 0.365), 84.1% and 91.2% (<i>p</i> = 0.185), and 88.4% and 92.1% (<i>p</i> = 0.276), respectively, after PSM. Multivariate analysis showed that three lymph node metastases were prognostic for LRC and DFS rates and LVI for OS rate. Arm lymphedema developed in 32.4% of patients who received PMRT, which was significantly higher than the non-PMRT group (<i>p</i> < 0.001). Contributions of PMRT for improvement of treatments outcomes in T1-2N1 breast cancer patients were not evident, while the incidence of arm lymphedema significantly increased after PMRT. Further prospective trials are required to re-evaluate the role of PMRT.https://www.mdpi.com/2072-6694/15/22/5473breast cancermastectomypost-mastectomy radiotherapyT1-2N1 |
| spellingShingle | Kangpyo Kim Won Park Haeyoung Kim Won Kyung Cho Nalee Kim Seok Jin Nam Seok Won Kim Jeong Eon Lee Jonghan Yu Byung Joo Chae Se Kyung Lee Jai Min Ryu The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis Cancers breast cancer mastectomy post-mastectomy radiotherapy T1-2N1 |
| title | The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis |
| title_full | The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis |
| title_fullStr | The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis |
| title_full_unstemmed | The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis |
| title_short | The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis |
| title_sort | role of post mastectomy radiotherapy in t1 2n1 breast cancer patients propensity score matched analysis |
| topic | breast cancer mastectomy post-mastectomy radiotherapy T1-2N1 |
| url | https://www.mdpi.com/2072-6694/15/22/5473 |
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