Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds
Recurrent bacterial infection is a major problem that threatens the tissue repair process. However, most current therapeutic strategies fail to deal with management of the overlap dynamics of bacterial killing and tissue repair. Here, in accord with the different responses of eukaryotic and prokaryo...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000904 |
| _version_ | 1811221437542825984 |
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| author | Weizhou Ren Zefeng Lin Youzhun Fan Jun Xing Guangyu Liu Taizhong Xiao Zhengao Wang Zhengnan Zhou Tao Zhang Zhiguo Song Peng Yu Chengyun Ning |
| author_facet | Weizhou Ren Zefeng Lin Youzhun Fan Jun Xing Guangyu Liu Taizhong Xiao Zhengao Wang Zhengnan Zhou Tao Zhang Zhiguo Song Peng Yu Chengyun Ning |
| author_sort | Weizhou Ren |
| collection | DOAJ |
| description | Recurrent bacterial infection is a major problem that threatens the tissue repair process. However, most current therapeutic strategies fail to deal with management of the overlap dynamics of bacterial killing and tissue repair. Here, in accord with the different responses of eukaryotic and prokaryotic cells to electric potential, we developed high performance photoelectric BiOCl nanosheets that dynamically switch between conditions that favor either tissue regrowth or antibacterial microenvironments due to light stimulated and bi-modal switching of their surface electrical polarization. In vitro assays demonstrate that, under light illumination, the mannitol modified BiOCl nanosheets show high relative surface potential and achieve robust antibacterial performance. Conversely, under dark conditions, the nanosheets exhibit relatively low surface potential and promote Bone Marrow Stem Cell (BMSCs) proliferation. In vivo studies indicate that BiOCl nanosheets with light switch capabilities promote the significant regeneration of infected skin wounds. This work offers a new insight into treating recurrent bacterial infections with photoelectric biomaterials for light controlled selection of alternative electrical microenvironments, thereby benefiting the capability for either antisepsis or repair of damaged tissues. |
| first_indexed | 2024-04-12T07:59:19Z |
| format | Article |
| id | doaj.art-e5fd9e421a7f4e84983a6da840ee109c |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-12T07:59:19Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-e5fd9e421a7f4e84983a6da840ee109c2022-12-22T03:41:23ZengElsevierMaterials Today Bio2590-00642022-06-0115100292Programmable biological state-switching photoelectric nanosheets for the treatment of infected woundsWeizhou Ren0Zefeng Lin1Youzhun Fan2Jun Xing3Guangyu Liu4Taizhong Xiao5Zhengao Wang6Zhengnan Zhou7Tao Zhang8Zhiguo Song9Peng Yu10Chengyun Ning11School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, China; Guangdong Key Lab of Orthopedic Technology and Implant, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, ChinaSchool of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, ChinaSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, ChinaGuangdong Key Lab of Orthopedic Technology and Implant, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China; Corresponding author.School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, China; Corresponding author.School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, China; Corresponding author.School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong, South China University of Technology, Guangzhou, 510641, China; China-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 510000, ChinaRecurrent bacterial infection is a major problem that threatens the tissue repair process. However, most current therapeutic strategies fail to deal with management of the overlap dynamics of bacterial killing and tissue repair. Here, in accord with the different responses of eukaryotic and prokaryotic cells to electric potential, we developed high performance photoelectric BiOCl nanosheets that dynamically switch between conditions that favor either tissue regrowth or antibacterial microenvironments due to light stimulated and bi-modal switching of their surface electrical polarization. In vitro assays demonstrate that, under light illumination, the mannitol modified BiOCl nanosheets show high relative surface potential and achieve robust antibacterial performance. Conversely, under dark conditions, the nanosheets exhibit relatively low surface potential and promote Bone Marrow Stem Cell (BMSCs) proliferation. In vivo studies indicate that BiOCl nanosheets with light switch capabilities promote the significant regeneration of infected skin wounds. This work offers a new insight into treating recurrent bacterial infections with photoelectric biomaterials for light controlled selection of alternative electrical microenvironments, thereby benefiting the capability for either antisepsis or repair of damaged tissues.http://www.sciencedirect.com/science/article/pii/S2590006422000904Bacterial infectionPhotoelectric nanosheetsLight-responsiveAntibacterialTissue reconstruction |
| spellingShingle | Weizhou Ren Zefeng Lin Youzhun Fan Jun Xing Guangyu Liu Taizhong Xiao Zhengao Wang Zhengnan Zhou Tao Zhang Zhiguo Song Peng Yu Chengyun Ning Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds Materials Today Bio Bacterial infection Photoelectric nanosheets Light-responsive Antibacterial Tissue reconstruction |
| title | Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds |
| title_full | Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds |
| title_fullStr | Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds |
| title_full_unstemmed | Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds |
| title_short | Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds |
| title_sort | programmable biological state switching photoelectric nanosheets for the treatment of infected wounds |
| topic | Bacterial infection Photoelectric nanosheets Light-responsive Antibacterial Tissue reconstruction |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000904 |
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