Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?
BackgroundThe obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). The primary objective was to understand the association between body mass index (BMI) and heart failure with reduced ej...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1239722/full |
| _version_ | 1797397174394290176 |
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| author | Nathália Felix Araujo Salvino Nathália Felix Araujo Salvino Lyz Tavares de Sousa Fabio Maia Abrahao Pedro Pimenta de Mello Spineti Ana Luiza Ferreira Sales Felipe Neves de Albuquerque Marcelo Imbroinise Bittencourt Pedro Castello Branco de Moraes Pedro Castello Branco de Moraes Roberto Esporcatte Ricardo Mourilhe-Rocha Ricardo Mourilhe-Rocha |
| author_facet | Nathália Felix Araujo Salvino Nathália Felix Araujo Salvino Lyz Tavares de Sousa Fabio Maia Abrahao Pedro Pimenta de Mello Spineti Ana Luiza Ferreira Sales Felipe Neves de Albuquerque Marcelo Imbroinise Bittencourt Pedro Castello Branco de Moraes Pedro Castello Branco de Moraes Roberto Esporcatte Ricardo Mourilhe-Rocha Ricardo Mourilhe-Rocha |
| author_sort | Nathália Felix Araujo Salvino |
| collection | DOAJ |
| description | BackgroundThe obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). The primary objective was to understand the association between body mass index (BMI) and heart failure with reduced ejection fraction (HFREF) of ischemic etiology in outpatients, using mortality as a parameter. The secondary objectives were to determine the differences in HF functional class, pharmacological therapy and evaluate the prognostic value of MAGGIC Score in this population.MethodsWe analyzed 1,556 medical records from the HF outpatient clinic of a quaternary hospital and 242 were selected according to the criteria. Most were male, average age 62.6 (56–70), BMI 18.5–24.9 = 35.1%, 25–29.9 = 37.2%, 30–34.9 = 17.8%, 35–39.9 = 7%; BMI <18.5 and >40 groups were eliminated from the central analyzes because of scarce testing.ResultsBMI 30–34.9 and BMI 18.5–24.9 had the best prognosis, BMI 25–29.9 had an average performance, and BMI –39.9 group provided the worst outcome (p = 0.123). In the subcategory analysis, BMI 30–34.9 group had a better prognosis compared to the BMI 35–39.9 group (p = 0.033). In the multivariate analysis The MAGGIC score was not able to foretell mortality in this population according to BMI.ConclusionIn not hospitalized patients with HFREF of ischemic etiology, obesity was not a protective factor. |
| first_indexed | 2024-03-09T01:06:10Z |
| format | Article |
| id | doaj.art-e5fea95368204f2aa7f324a6796a3fcb |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T01:06:10Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e5fea95368204f2aa7f324a6796a3fcb2023-12-11T10:04:40ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.12397221239722Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?Nathália Felix Araujo Salvino0Nathália Felix Araujo Salvino1Lyz Tavares de Sousa2Fabio Maia Abrahao3Pedro Pimenta de Mello Spineti4Ana Luiza Ferreira Sales5Felipe Neves de Albuquerque6Marcelo Imbroinise Bittencourt7Pedro Castello Branco de Moraes8Pedro Castello Branco de Moraes9Roberto Esporcatte10Ricardo Mourilhe-Rocha11Ricardo Mourilhe-Rocha12Serviço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilComplexo Hospital Americas - Vitória e Samaritano - Barra da Tijuca, Rio de Janeiro, BrazilUniversidade Estácio de Sá, Departamento de medicina, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilComplexo Hospital Americas - Vitória e Samaritano - Barra da Tijuca, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilServiço e Disciplina de Cardiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilComplexo Hospital Americas - Vitória e Samaritano - Barra da Tijuca, Rio de Janeiro, BrazilBackgroundThe obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). The primary objective was to understand the association between body mass index (BMI) and heart failure with reduced ejection fraction (HFREF) of ischemic etiology in outpatients, using mortality as a parameter. The secondary objectives were to determine the differences in HF functional class, pharmacological therapy and evaluate the prognostic value of MAGGIC Score in this population.MethodsWe analyzed 1,556 medical records from the HF outpatient clinic of a quaternary hospital and 242 were selected according to the criteria. Most were male, average age 62.6 (56–70), BMI 18.5–24.9 = 35.1%, 25–29.9 = 37.2%, 30–34.9 = 17.8%, 35–39.9 = 7%; BMI <18.5 and >40 groups were eliminated from the central analyzes because of scarce testing.ResultsBMI 30–34.9 and BMI 18.5–24.9 had the best prognosis, BMI 25–29.9 had an average performance, and BMI –39.9 group provided the worst outcome (p = 0.123). In the subcategory analysis, BMI 30–34.9 group had a better prognosis compared to the BMI 35–39.9 group (p = 0.033). In the multivariate analysis The MAGGIC score was not able to foretell mortality in this population according to BMI.ConclusionIn not hospitalized patients with HFREF of ischemic etiology, obesity was not a protective factor.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1239722/fullobesity paradoxheart failureobesityMAGGIC scoreheart failure reduced ejection fraction |
| spellingShingle | Nathália Felix Araujo Salvino Nathália Felix Araujo Salvino Lyz Tavares de Sousa Fabio Maia Abrahao Pedro Pimenta de Mello Spineti Ana Luiza Ferreira Sales Felipe Neves de Albuquerque Marcelo Imbroinise Bittencourt Pedro Castello Branco de Moraes Pedro Castello Branco de Moraes Roberto Esporcatte Ricardo Mourilhe-Rocha Ricardo Mourilhe-Rocha Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? Frontiers in Cardiovascular Medicine obesity paradox heart failure obesity MAGGIC score heart failure reduced ejection fraction |
| title | Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? |
| title_full | Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? |
| title_fullStr | Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? |
| title_full_unstemmed | Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? |
| title_short | Is the obesity paradox in outpatients with heart failure reduced ejection fraction real? |
| title_sort | is the obesity paradox in outpatients with heart failure reduced ejection fraction real |
| topic | obesity paradox heart failure obesity MAGGIC score heart failure reduced ejection fraction |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1239722/full |
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