A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
Abstract Background In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak reve...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-10-01
|
| Series: | Virology Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12985-018-1082-8 |
| _version_ | 1819211601782243328 |
|---|---|
| author | Bo Wang Olusola Anuoluwapo Akanbi Dominik Harms Olufisayo Adesina Folakemi Abiodun Osundare Dhamari Naidoo Isabel Deveaux Opeayo Ogundiran Uzoma Ugochukwu Nwando Mba Chikwe Ihekweazu C.-Thomas Bock |
| author_facet | Bo Wang Olusola Anuoluwapo Akanbi Dominik Harms Olufisayo Adesina Folakemi Abiodun Osundare Dhamari Naidoo Isabel Deveaux Opeayo Ogundiran Uzoma Ugochukwu Nwando Mba Chikwe Ihekweazu C.-Thomas Bock |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | Abstract Background In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. Finding The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). Conclusions We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation. |
| first_indexed | 2024-12-23T06:29:40Z |
| format | Article |
| id | doaj.art-e5feeb6be79742a49ee40681de3ae92d |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-23T06:29:40Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-e5feeb6be79742a49ee40681de3ae92d2022-12-21T17:56:59ZengBMCVirology Journal1743-422X2018-10-011511610.1186/s12985-018-1082-8A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017Bo Wang0Olusola Anuoluwapo Akanbi1Dominik Harms2Olufisayo Adesina3Folakemi Abiodun Osundare4Dhamari Naidoo5Isabel Deveaux6Opeayo Ogundiran7Uzoma Ugochukwu8Nwando Mba9Chikwe Ihekweazu10C.-Thomas Bock11Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteInfectious Hazard Management Department, World Health OrganizationNigeria Centre for Disease ControlNigeria Centre for Disease ControlNigeria Centre for Disease ControlNigeria Centre for Disease ControlNigeria Centre for Disease ControlDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch InstituteAbstract Background In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. Finding The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). Conclusions We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.http://link.springer.com/article/10.1186/s12985-018-1082-8Hepatitis E virusHEV genotype 2HEV subtype 2bOutbreakNigeriaComplete genome |
| spellingShingle | Bo Wang Olusola Anuoluwapo Akanbi Dominik Harms Olufisayo Adesina Folakemi Abiodun Osundare Dhamari Naidoo Isabel Deveaux Opeayo Ogundiran Uzoma Ugochukwu Nwando Mba Chikwe Ihekweazu C.-Thomas Bock A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 Virology Journal Hepatitis E virus HEV genotype 2 HEV subtype 2b Outbreak Nigeria Complete genome |
| title | A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 |
| title_full | A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 |
| title_fullStr | A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 |
| title_full_unstemmed | A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 |
| title_short | A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 |
| title_sort | new hepatitis e virus genotype 2 strain identified from an outbreak in nigeria 2017 |
| topic | Hepatitis E virus HEV genotype 2 HEV subtype 2b Outbreak Nigeria Complete genome |
| url | http://link.springer.com/article/10.1186/s12985-018-1082-8 |
| work_keys_str_mv | AT bowang anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT olusolaanuoluwapoakanbi anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT dominikharms anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT olufisayoadesina anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT folakemiabiodunosundare anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT dhamarinaidoo anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT isabeldeveaux anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT opeayoogundiran anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT uzomaugochukwu anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT nwandomba anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT chikweihekweazu anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT cthomasbock anewhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT bowang newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT olusolaanuoluwapoakanbi newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT dominikharms newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT olufisayoadesina newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT folakemiabiodunosundare newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT dhamarinaidoo newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT isabeldeveaux newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT opeayoogundiran newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT uzomaugochukwu newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT nwandomba newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT chikweihekweazu newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 AT cthomasbock newhepatitisevirusgenotype2strainidentifiedfromanoutbreakinnigeria2017 |