Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study
Abstract Aims/Introduction We estimated the hazards of cardiovascular diseases (CVDs) and early all‐cause mortality in Korean adults according to the presence of recently diagnosed type 2 diabetes (type 2 diabetes for <5 years) and insulin use. Materials and Methods We used the Korean National He...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-10-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13539 |
| _version_ | 1819015488653492224 |
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| author | You‐Bin Lee Kyungdo Han Bongsung Kim Min Sun Choi Jiyun Park Minyoung Kim Sang‐Man Jin Kyu Yeon Hur Gyuri Kim Jae Hyeon Kim |
| author_facet | You‐Bin Lee Kyungdo Han Bongsung Kim Min Sun Choi Jiyun Park Minyoung Kim Sang‐Man Jin Kyu Yeon Hur Gyuri Kim Jae Hyeon Kim |
| author_sort | You‐Bin Lee |
| collection | DOAJ |
| description | Abstract Aims/Introduction We estimated the hazards of cardiovascular diseases (CVDs) and early all‐cause mortality in Korean adults according to the presence of recently diagnosed type 2 diabetes (type 2 diabetes for <5 years) and insulin use. Materials and Methods We used the Korean National Health Insurance Service–National Sample Cohort database (2002–2015) for this longitudinal population‐based study. Among adults aged ≥40 years without baseline CVD, individuals without diabetes or with recently diagnosed type 2 diabetes were selected (N = 363,919). The hazard ratios (HRs) for myocardial infarction (MI), stroke, and all‐cause mortality during follow‐up were analyzed according to three groups categorized by the presence of type 2 diabetes and insulin use. Results Within a mean 7.8 years, there were 5,275 MIs, 7,220 strokes, and 15,834 deaths. The hazards for outcomes were higher in the insulin‐treated type 2 diabetes group than in the non‐diabetes group [HR (95% CI): 2.344 (1.870–2.938) for MI, 2.420 (1.993–2.937) for stroke, and 3.037 (2.706–3.407) for death], higher in the non‐insulin‐treated type 2 diabetes group than in the non‐diabetes group [HR (95% CI): 1.284 (1.159–1.423) for MI, 1.435 (1.320–1.561) for stroke, and 1.135 (1.067–1.206) for death], and higher in the insulin‐treated type 2 diabetes group than in the non‐insulin‐treated type 2 diabetes group [HR (95% CI): 1.914 (1.502–2.441) for MI, 1.676 (1.363–2.060) for stroke, and 2.535 (2.232–2.880) for death]. Conclusions Recently diagnosed type 2 diabetes patients showed increased risks of incident CVDs and premature mortality, and insulin‐treated group demonstrated an additional increase in the risks of these outcomes in adults with recently diagnosed type 2 diabetes, suggesting the need for intensified cardio‐protective interventions for adults with insulin‐treated type 2 diabetes. |
| first_indexed | 2024-12-21T02:32:32Z |
| format | Article |
| id | doaj.art-e5ff28b5ef9546c68b1888ff8db75309 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-21T02:32:32Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-e5ff28b5ef9546c68b1888ff8db753092022-12-21T19:18:53ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-10-0112101855186310.1111/jdi.13539Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide studyYou‐Bin Lee0Kyungdo Han1Bongsung Kim2Min Sun Choi3Jiyun Park4Minyoung Kim5Sang‐Man Jin6Kyu Yeon Hur7Gyuri Kim8Jae Hyeon Kim9Division of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDepartment of Statistics and Actuarial Science Soongsil University Seoul KoreaDepartment of Statistics and Actuarial Science Soongsil University Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDivision of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaAbstract Aims/Introduction We estimated the hazards of cardiovascular diseases (CVDs) and early all‐cause mortality in Korean adults according to the presence of recently diagnosed type 2 diabetes (type 2 diabetes for <5 years) and insulin use. Materials and Methods We used the Korean National Health Insurance Service–National Sample Cohort database (2002–2015) for this longitudinal population‐based study. Among adults aged ≥40 years without baseline CVD, individuals without diabetes or with recently diagnosed type 2 diabetes were selected (N = 363,919). The hazard ratios (HRs) for myocardial infarction (MI), stroke, and all‐cause mortality during follow‐up were analyzed according to three groups categorized by the presence of type 2 diabetes and insulin use. Results Within a mean 7.8 years, there were 5,275 MIs, 7,220 strokes, and 15,834 deaths. The hazards for outcomes were higher in the insulin‐treated type 2 diabetes group than in the non‐diabetes group [HR (95% CI): 2.344 (1.870–2.938) for MI, 2.420 (1.993–2.937) for stroke, and 3.037 (2.706–3.407) for death], higher in the non‐insulin‐treated type 2 diabetes group than in the non‐diabetes group [HR (95% CI): 1.284 (1.159–1.423) for MI, 1.435 (1.320–1.561) for stroke, and 1.135 (1.067–1.206) for death], and higher in the insulin‐treated type 2 diabetes group than in the non‐insulin‐treated type 2 diabetes group [HR (95% CI): 1.914 (1.502–2.441) for MI, 1.676 (1.363–2.060) for stroke, and 2.535 (2.232–2.880) for death]. Conclusions Recently diagnosed type 2 diabetes patients showed increased risks of incident CVDs and premature mortality, and insulin‐treated group demonstrated an additional increase in the risks of these outcomes in adults with recently diagnosed type 2 diabetes, suggesting the need for intensified cardio‐protective interventions for adults with insulin‐treated type 2 diabetes.https://doi.org/10.1111/jdi.13539InsulinMortalityType 2 diabetes mellitus |
| spellingShingle | You‐Bin Lee Kyungdo Han Bongsung Kim Min Sun Choi Jiyun Park Minyoung Kim Sang‐Man Jin Kyu Yeon Hur Gyuri Kim Jae Hyeon Kim Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study Journal of Diabetes Investigation Insulin Mortality Type 2 diabetes mellitus |
| title | Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study |
| title_full | Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study |
| title_fullStr | Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study |
| title_full_unstemmed | Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study |
| title_short | Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study |
| title_sort | risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment a nationwide study |
| topic | Insulin Mortality Type 2 diabetes mellitus |
| url | https://doi.org/10.1111/jdi.13539 |
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