In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity
Mediterranean-native perennial plant Antirrhinum majus was scrutinized in this study for its antioxidant activity and its total phenolic content in order to test for the plant’s wound-healing capability. The traditional uses of this plant to treat gum scurvy, various tumors, ulcers, and he...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | http://www.mdpi.com/2218-0532/86/4/45 |
| _version_ | 1811262993391943680 |
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| author | Fadi G. Saqallah Wafaa M. Hamed Wamidh H. Talib |
| author_facet | Fadi G. Saqallah Wafaa M. Hamed Wamidh H. Talib |
| author_sort | Fadi G. Saqallah |
| collection | DOAJ |
| description | Mediterranean-native perennial plant Antirrhinum majus was scrutinized in this study for its antioxidant activity and its total phenolic content in order to test for the plant’s wound-healing capability. The traditional uses of this plant to treat gum scurvy, various tumors, ulcers, and hemorrhoids were the main idea behind this study. Leaves and flowers of the A. majus were extracted by maceration. Pilot qualitative phytochemical tests were made to check the presence of various secondary metabolites. Quantitatively, the flowers’ macerate indicated superlative results regarding antioxidant activity and total phenolic content. However, the in vivo wound-healing capability study was made using 30 Wistar strain albino rats. This innovative part of the study revealed that the healing power of the flowers’ extract ointment (5% w/w) was superior compared to the leaves’ extract (5% w/w) and the positive-control ointments (MEBO) (1.5% w/w) (p ≤ 0.001). This activity was assessed by visual examination, wound-length measurement, and estimation of hydroxyproline content. Antirrhinum majus is a promising plant to be considered for wound healing. However, further testing (including histological examination and high-performance liquid chromatography (HPLC) analysis) is necessary to understand more about its mechanisms of action. |
| first_indexed | 2024-04-12T19:37:00Z |
| format | Article |
| id | doaj.art-e600a58fd04a404e90ba1052bc34fd7e |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-12T19:37:00Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-e600a58fd04a404e90ba1052bc34fd7e2022-12-22T03:19:11ZengMDPI AGScientia Pharmaceutica2218-05322018-10-018644510.3390/scipharm86040045scipharm86040045In Vivo Evaluation of Antirrhinum majus’ Wound-Healing ActivityFadi G. Saqallah0Wafaa M. Hamed1Wamidh H. Talib2Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, 11931 Amman, JordanDepartment of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, 11931 Amman, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, 11931 Amman, JordanMediterranean-native perennial plant Antirrhinum majus was scrutinized in this study for its antioxidant activity and its total phenolic content in order to test for the plant’s wound-healing capability. The traditional uses of this plant to treat gum scurvy, various tumors, ulcers, and hemorrhoids were the main idea behind this study. Leaves and flowers of the A. majus were extracted by maceration. Pilot qualitative phytochemical tests were made to check the presence of various secondary metabolites. Quantitatively, the flowers’ macerate indicated superlative results regarding antioxidant activity and total phenolic content. However, the in vivo wound-healing capability study was made using 30 Wistar strain albino rats. This innovative part of the study revealed that the healing power of the flowers’ extract ointment (5% w/w) was superior compared to the leaves’ extract (5% w/w) and the positive-control ointments (MEBO) (1.5% w/w) (p ≤ 0.001). This activity was assessed by visual examination, wound-length measurement, and estimation of hydroxyproline content. Antirrhinum majus is a promising plant to be considered for wound healing. However, further testing (including histological examination and high-performance liquid chromatography (HPLC) analysis) is necessary to understand more about its mechanisms of action.http://www.mdpi.com/2218-0532/86/4/45Antirrhinum majusmaceration extractionantioxidant activitytotal phenolic contentwound healing |
| spellingShingle | Fadi G. Saqallah Wafaa M. Hamed Wamidh H. Talib In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity Scientia Pharmaceutica Antirrhinum majus maceration extraction antioxidant activity total phenolic content wound healing |
| title | In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity |
| title_full | In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity |
| title_fullStr | In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity |
| title_full_unstemmed | In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity |
| title_short | In Vivo Evaluation of Antirrhinum majus’ Wound-Healing Activity |
| title_sort | in vivo evaluation of antirrhinum majus wound healing activity |
| topic | Antirrhinum majus maceration extraction antioxidant activity total phenolic content wound healing |
| url | http://www.mdpi.com/2218-0532/86/4/45 |
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