High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy
Abstract Background C-reactive protein (CRP) is an important biomarker of inflammation and plays a pivotal role in predicting the clinical prognosis of cardiovascular and cerebrovascular diseases. However, the mechanism of inflammation influencing the outcome of patients with ischemic stroke are unk...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00705-z |
| _version_ | 1818553397079441408 |
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| author | Tan Li Qiannan Yu Yiqing Wang Xiuying Cai Yan Kong Hongru Zhao Shanshan Diao Yiren Qin Qi Fang |
| author_facet | Tan Li Qiannan Yu Yiqing Wang Xiuying Cai Yan Kong Hongru Zhao Shanshan Diao Yiren Qin Qi Fang |
| author_sort | Tan Li |
| collection | DOAJ |
| description | Abstract Background C-reactive protein (CRP) is an important biomarker of inflammation and plays a pivotal role in predicting the clinical prognosis of cardiovascular and cerebrovascular diseases. However, the mechanism of inflammation influencing the outcome of patients with ischemic stroke are unknown. Aims We aim to investigate the association between hsCRP and mRS in 194 eligible patients by therapy-stratified analyses. Methods The modification effects of antiplatelet therapy on the association between mRS and different exposure variables were analyzed. The retained variables were analyzed in the receiver operating characteristic (ROC) curve to discriminate patients with poor outcome. Results hsCRP was positively correlated with mRS in therapy-stratified analyses. There was a statistical modification effect of antiplatelet therapy on the association of hsCRP and mRS (P for interaction = 0.0101). The discriminative effect of poor outcome was further verified by ROC curve analyses (AUCwith from 0.758 to 0.872, AUCwithout from 0.709 to 0.713). Conclusions hsCRP is correlated with the clinical outcome of patients treated with IVrt-PA, and may be a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy than in non-used patients. |
| first_indexed | 2024-12-12T09:25:18Z |
| format | Article |
| id | doaj.art-e600f9e4a4b745eeb308c5203328a741 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-12T09:25:18Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-e600f9e4a4b745eeb308c5203328a7412022-12-22T00:29:03ZengBMCEuropean Journal of Medical Research2047-783X2022-06-012711810.1186/s40001-022-00705-zHigh-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapyTan Li0Qiannan Yu1Yiqing Wang2Xiuying Cai3Yan Kong4Hongru Zhao5Shanshan Diao6Yiren Qin7Qi Fang8Stroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityStroke Center, The First Affiliated Hospital of Soochow UniversityAbstract Background C-reactive protein (CRP) is an important biomarker of inflammation and plays a pivotal role in predicting the clinical prognosis of cardiovascular and cerebrovascular diseases. However, the mechanism of inflammation influencing the outcome of patients with ischemic stroke are unknown. Aims We aim to investigate the association between hsCRP and mRS in 194 eligible patients by therapy-stratified analyses. Methods The modification effects of antiplatelet therapy on the association between mRS and different exposure variables were analyzed. The retained variables were analyzed in the receiver operating characteristic (ROC) curve to discriminate patients with poor outcome. Results hsCRP was positively correlated with mRS in therapy-stratified analyses. There was a statistical modification effect of antiplatelet therapy on the association of hsCRP and mRS (P for interaction = 0.0101). The discriminative effect of poor outcome was further verified by ROC curve analyses (AUCwith from 0.758 to 0.872, AUCwithout from 0.709 to 0.713). Conclusions hsCRP is correlated with the clinical outcome of patients treated with IVrt-PA, and may be a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy than in non-used patients.https://doi.org/10.1186/s40001-022-00705-zhsCRPmRSrt-PANIHSSAntiplatelet |
| spellingShingle | Tan Li Qiannan Yu Yiqing Wang Xiuying Cai Yan Kong Hongru Zhao Shanshan Diao Yiren Qin Qi Fang High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy European Journal of Medical Research hsCRP mRS rt-PA NIHSS Antiplatelet |
| title | High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy |
| title_full | High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy |
| title_fullStr | High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy |
| title_full_unstemmed | High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy |
| title_short | High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with previous antiplatelet therapy |
| title_sort | high sensitivity c reactive protein as a better predictor of post thrombolytic functional outcome in patients with previous antiplatelet therapy |
| topic | hsCRP mRS rt-PA NIHSS Antiplatelet |
| url | https://doi.org/10.1186/s40001-022-00705-z |
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