The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney
Background & Objectives: Lead as a naturally-occurring element has different effects on hematopoitic system, nervous system, kidney, reproductive system and bone. In this investigation, was determined the effect of garlic alcoholic-water extract in kidney poisoning treatment induced by lead in n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2014-05-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-584-en.pdf |
| _version_ | 1797679724220121088 |
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| author | Habibollah Johari Zahra Zamani Mokhtar Mokhtari Vahid Hemayatkhah Jahromi Houshang Jamali Mohammad Yazdani |
| author_facet | Habibollah Johari Zahra Zamani Mokhtar Mokhtari Vahid Hemayatkhah Jahromi Houshang Jamali Mohammad Yazdani |
| author_sort | Habibollah Johari |
| collection | DOAJ |
| description | Background & Objectives: Lead as a naturally-occurring element has different effects on
hematopoitic system, nervous system, kidney, reproductive system and bone. In
this investigation, was determined the effect of garlic alcoholic-water extract
in kidney poisoning treatment induced by lead in neonatal rat.Materials & Methods: Rats were divided into 7 groups of 8. The First group was the control group, which had received no materials. The second group had received 0/1 ml distilled water, the third group had received the lead with a dose of 0/6 gram per liter. The forth group had just received 0/4 g/kg garlic alcoholic – water extract. The fifth, sixth, and seventh group had first received 0/6 g lead perliter and then received doses of 0/1, 0/2, 0/4 g/kg garlic. Then, injections was performed orally in 10 consecutive days. The data were analysed then using T.
Results: Based on the obtained results, there is a significant increase in the body weight and the kidney of the third, fifth, sixth and seventh groups compared with the control group. However, the body weight and kidney of rats in the fourth group showed a meaningful decrease comparing with the lead group. Regarding the third group, there was a meaningful increase in Urea, uric acid, creatinine and potassium compared with the control group but a significant decrease in the sodium.
Conclusion: Protective effects of garlic on kidney are related to antioxidant properties, since different types of oxidation reactions have negative effects on glomerular filtration rate. Garlic is eliminating the poisoning effect of lead on the kidney because of having properties such as antioxidant and protective effect. |
| first_indexed | 2024-03-11T23:19:02Z |
| format | Article |
| id | doaj.art-e60117efe2d1442e994c394f7f055945 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:19:02Z |
| publishDate | 2014-05-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-e60117efe2d1442e994c394f7f0559452023-09-20T21:17:19ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232014-05-01419098The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats KidneyHabibollah Johari0Zahra Zamani1Mokhtar Mokhtari2Vahid Hemayatkhah Jahromi3Houshang Jamali4Mohammad Yazdani5 Background & Objectives: Lead as a naturally-occurring element has different effects on hematopoitic system, nervous system, kidney, reproductive system and bone. In this investigation, was determined the effect of garlic alcoholic-water extract in kidney poisoning treatment induced by lead in neonatal rat.Materials & Methods: Rats were divided into 7 groups of 8. The First group was the control group, which had received no materials. The second group had received 0/1 ml distilled water, the third group had received the lead with a dose of 0/6 gram per liter. The forth group had just received 0/4 g/kg garlic alcoholic – water extract. The fifth, sixth, and seventh group had first received 0/6 g lead perliter and then received doses of 0/1, 0/2, 0/4 g/kg garlic. Then, injections was performed orally in 10 consecutive days. The data were analysed then using T. Results: Based on the obtained results, there is a significant increase in the body weight and the kidney of the third, fifth, sixth and seventh groups compared with the control group. However, the body weight and kidney of rats in the fourth group showed a meaningful decrease comparing with the lead group. Regarding the third group, there was a meaningful increase in Urea, uric acid, creatinine and potassium compared with the control group but a significant decrease in the sodium. Conclusion: Protective effects of garlic on kidney are related to antioxidant properties, since different types of oxidation reactions have negative effects on glomerular filtration rate. Garlic is eliminating the poisoning effect of lead on the kidney because of having properties such as antioxidant and protective effect.http://jabs.fums.ac.ir/article-1-584-en.pdfgarlicleadkidneyrat. |
| spellingShingle | Habibollah Johari Zahra Zamani Mokhtar Mokhtari Vahid Hemayatkhah Jahromi Houshang Jamali Mohammad Yazdani The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney Journal of Advanced Biomedical Sciences garlic lead kidney rat. |
| title | The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney |
| title_full | The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney |
| title_fullStr | The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney |
| title_full_unstemmed | The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney |
| title_short | The Investigation of Garlic (Allium Sativum) Extract on Lead Detoxification of Neonatal Rats Kidney |
| title_sort | investigation of garlic allium sativum extract on lead detoxification of neonatal rats kidney |
| topic | garlic lead kidney rat. |
| url | http://jabs.fums.ac.ir/article-1-584-en.pdf |
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