Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice

Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice

Although studies have shown that protein 53 (p53)-mediated ferroptosis is involved in acute lung injury (ALI), the mechanism of its regulation remains unclear. The protective effects of Sirtuin 6 (SIRT6), a histone deacetylase, have been demonstrated in multiple diseases; however, further studies ar...

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Bibliographic Details
Main Authors: Yuanyuan Cao, Tian Peng, Chenmu Ai, Zhiwang Li, Xiaobao Lei, Guicheng Li, Tao Li, Xiang Wang, Shumin Cai
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Acute lung injury
Ferroptosis
Protein 53
Sirtuin-6
Acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402309480X

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