Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography
Recently, supershear Rayleigh waves (SRWs) have been proposed to characterize the biomechanical properties of soft tissues. The SRWs propagate along the surface of the medium, unlike surface Rayleigh waves, SRWs propagate faster than bulk shear waves. However, their behavior and application in biolo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2023-12-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0160213 |
| _version_ | 1797367093594685440 |
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| author | Yirui Zhu Jiulin Shi Tomas E. Gomez Alvarez-arenas Chenxi Li Haohao Wang Hongling Cai Dong Zhang Xingdao He Xiaoshan Wu |
| author_facet | Yirui Zhu Jiulin Shi Tomas E. Gomez Alvarez-arenas Chenxi Li Haohao Wang Hongling Cai Dong Zhang Xingdao He Xiaoshan Wu |
| author_sort | Yirui Zhu |
| collection | DOAJ |
| description | Recently, supershear Rayleigh waves (SRWs) have been proposed to characterize the biomechanical properties of soft tissues. The SRWs propagate along the surface of the medium, unlike surface Rayleigh waves, SRWs propagate faster than bulk shear waves. However, their behavior and application in biological tissues is still elusive. In brain tissue elastography, shear waves combined with magnetic resonance elastography or ultrasound elastography are generally used to quantify the shear modulus, but high spatial resolution elasticity assessment in 10 μm scale is still improving. Here, we develop an air-coupled ultrasonic transducer for noncontact excitation of SRWs and Rayleigh waves in brain tissue, use optical coherent elastography (OCE) to detect, and reconstruct the SRW propagation process; in combing with a derived theoretical model of SRWs on a free boundary surface, we quantify the shear modulus of brain tissue with high spatial resolution. We first complete validation experiments using a homogeneous isotropic agar phantom, and the experimental results clearly show the SRW is 1.9649 times faster than the bulk shear waves. Furthermore, the propagation velocity of SRWs in both the frontal and parietal lobe regions of the brain is all 1.87 times faster than the bulk shear wave velocity. Finally, we evaluated the anisotropy in different brain regions, and the medulla oblongata region had the highest anisotropy index. Our study shows that the OCE system using the SRW model is a new potential approach for high-resolution assessment of the biomechanical properties of brain tissue. |
| first_indexed | 2024-03-08T17:12:21Z |
| format | Article |
| id | doaj.art-e602598bb8d24217aa2cd7eef0ae2eff |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-03-08T17:12:21Z |
| publishDate | 2023-12-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-e602598bb8d24217aa2cd7eef0ae2eff2024-01-03T19:58:04ZengAIP Publishing LLCAPL Bioengineering2473-28772023-12-0174046107046107-1110.1063/5.0160213Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastographyYirui Zhu0Jiulin Shi1Tomas E. Gomez Alvarez-arenas2Chenxi Li3Haohao Wang4Hongling Cai5Dong Zhang6Xingdao He7Xiaoshan Wu8 School of Testing and Opto-electric Engineering, Nanchang Hangkong University, Nanchang 330063, China School of Testing and Opto-electric Engineering, Nanchang Hangkong University, Nanchang 330063, China Ultrasonic and Sensors Technologies Department, Information and Physical Technologies Institute, Spanish National Research Council, Serrano 144, 28006 Madrid, Spain School of Testing and Opto-electric Engineering, Nanchang Hangkong University, Nanchang 330063, China School of Testing and Opto-electric Engineering, Nanchang Hangkong University, Nanchang 330063, China School of Physics, Nanjing University, Nanjing 210093, China School of Physics, Nanjing University, Nanjing 210093, China School of Testing and Opto-electric Engineering, Nanchang Hangkong University, Nanchang 330063, China School of Physics, Nanjing University, Nanjing 210093, ChinaRecently, supershear Rayleigh waves (SRWs) have been proposed to characterize the biomechanical properties of soft tissues. The SRWs propagate along the surface of the medium, unlike surface Rayleigh waves, SRWs propagate faster than bulk shear waves. However, their behavior and application in biological tissues is still elusive. In brain tissue elastography, shear waves combined with magnetic resonance elastography or ultrasound elastography are generally used to quantify the shear modulus, but high spatial resolution elasticity assessment in 10 μm scale is still improving. Here, we develop an air-coupled ultrasonic transducer for noncontact excitation of SRWs and Rayleigh waves in brain tissue, use optical coherent elastography (OCE) to detect, and reconstruct the SRW propagation process; in combing with a derived theoretical model of SRWs on a free boundary surface, we quantify the shear modulus of brain tissue with high spatial resolution. We first complete validation experiments using a homogeneous isotropic agar phantom, and the experimental results clearly show the SRW is 1.9649 times faster than the bulk shear waves. Furthermore, the propagation velocity of SRWs in both the frontal and parietal lobe regions of the brain is all 1.87 times faster than the bulk shear wave velocity. Finally, we evaluated the anisotropy in different brain regions, and the medulla oblongata region had the highest anisotropy index. Our study shows that the OCE system using the SRW model is a new potential approach for high-resolution assessment of the biomechanical properties of brain tissue.http://dx.doi.org/10.1063/5.0160213 |
| spellingShingle | Yirui Zhu Jiulin Shi Tomas E. Gomez Alvarez-arenas Chenxi Li Haohao Wang Hongling Cai Dong Zhang Xingdao He Xiaoshan Wu Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography APL Bioengineering |
| title | Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography |
| title_full | Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography |
| title_fullStr | Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography |
| title_full_unstemmed | Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography |
| title_short | Supershear Rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air-coupled optical coherence elastography |
| title_sort | supershear rayleigh wave imaging for quantitative assessment of biomechanical properties of brain using air coupled optical coherence elastography |
| url | http://dx.doi.org/10.1063/5.0160213 |
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