INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation

INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation

Abstract Background Osteosarcoma (OS) is a refractory malignancy. This study aimed to explore the roles and mechanisms of Inhibin subunit beta A (INHBA) in OS. Methods INHBA expression levels in OS tissues and cells were assessed using RT-qPCR and western blotting. The impact of INHBA silencing on O...

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Bibliographic Details
Main Authors: Hongyu Zhang, Yuemei Huang, Qiuting Wen, Yan Li, Lin Guo, Na Ge
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
INHBA
Osteosarcoma
Cell proliferation, migration, and invasion
TGF-β signaling pathway
Online Access:https://doi.org/10.1186/s13018-023-04330-2

Internet

https://doi.org/10.1186/s13018-023-04330-2

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