Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring
Selenium deficiency during the perinatal period programs metabolic dysfunction in offspring. Postnatal exercise may prevent the development of programmed metabolic disease. This study investigated the impact of selenium deficiency on offspring exercise behavior and whether this improved metabolic he...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/5/1125 |
| _version_ | 1797474194242404352 |
|---|---|
| author | Pierre Hofstee Anthony V. Perkins James S. M. Cuffe |
| author_facet | Pierre Hofstee Anthony V. Perkins James S. M. Cuffe |
| author_sort | Pierre Hofstee |
| collection | DOAJ |
| description | Selenium deficiency during the perinatal period programs metabolic dysfunction in offspring. Postnatal exercise may prevent the development of programmed metabolic disease. This study investigated the impact of selenium deficiency on offspring exercise behavior and whether this improved metabolic health. Female C57BL/6 mice were randomly allocated to control (NormalSe, >190 μg/Se/kg, <i>n</i> = 8) or low-selenium (LowSe, <50 μg/Se/kg, <i>n</i> = 8) diets from four weeks before mating. Male offspring were weaned at postnatal day (PN) twenty-four and placed on a normal chow diet. At PN60, mice were placed in cages with bi-directional running wheels and monitored until PN180. LowSe offspring had a reduced average weekly running speed and distance (<i>p</i> < 0.05). LowSe offspring exhibited glucose intolerance, with increased peak blood glucose (<i>p</i> < 0.05) and area under the curve following an intra-peritoneal injection of glucose (<i>p</i> < 0.05). Furthermore, mRNA expression of several selenoproteins within cardiac and skeletal muscle were increased in LowSe offspring (<i>p</i> < 0.05). The results indicated that selenium deficiency during development reduces exercise behavior. Furthermore, exercise does not prevent programmed glucose intolerance in low-selenium offspring. This highlights that exercise may not be the optimal intervention for metabolic disease in offspring impacted by selenium deficiency in early life. |
| first_indexed | 2024-03-09T20:26:41Z |
| format | Article |
| id | doaj.art-e603db275bcd4e99852a57ac938be885 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:41Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e603db275bcd4e99852a57ac938be8852023-11-23T23:34:55ZengMDPI AGNutrients2072-66432022-03-01145112510.3390/nu14051125Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult OffspringPierre Hofstee0Anthony V. Perkins1James S. M. Cuffe2School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, QLD 4215, AustraliaSchool of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, QLD 4215, AustraliaThe School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, AustraliaSelenium deficiency during the perinatal period programs metabolic dysfunction in offspring. Postnatal exercise may prevent the development of programmed metabolic disease. This study investigated the impact of selenium deficiency on offspring exercise behavior and whether this improved metabolic health. Female C57BL/6 mice were randomly allocated to control (NormalSe, >190 μg/Se/kg, <i>n</i> = 8) or low-selenium (LowSe, <50 μg/Se/kg, <i>n</i> = 8) diets from four weeks before mating. Male offspring were weaned at postnatal day (PN) twenty-four and placed on a normal chow diet. At PN60, mice were placed in cages with bi-directional running wheels and monitored until PN180. LowSe offspring had a reduced average weekly running speed and distance (<i>p</i> < 0.05). LowSe offspring exhibited glucose intolerance, with increased peak blood glucose (<i>p</i> < 0.05) and area under the curve following an intra-peritoneal injection of glucose (<i>p</i> < 0.05). Furthermore, mRNA expression of several selenoproteins within cardiac and skeletal muscle were increased in LowSe offspring (<i>p</i> < 0.05). The results indicated that selenium deficiency during development reduces exercise behavior. Furthermore, exercise does not prevent programmed glucose intolerance in low-selenium offspring. This highlights that exercise may not be the optimal intervention for metabolic disease in offspring impacted by selenium deficiency in early life.https://www.mdpi.com/2072-6643/14/5/1125physical activityDOHaDmetabolismselenoproteins |
| spellingShingle | Pierre Hofstee Anthony V. Perkins James S. M. Cuffe Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring Nutrients physical activity DOHaD metabolism selenoproteins |
| title | Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring |
| title_full | Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring |
| title_fullStr | Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring |
| title_full_unstemmed | Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring |
| title_short | Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring |
| title_sort | selenium deficiency during pregnancy in mice impairs exercise performance and metabolic function in adult offspring |
| topic | physical activity DOHaD metabolism selenoproteins |
| url | https://www.mdpi.com/2072-6643/14/5/1125 |
| work_keys_str_mv | AT pierrehofstee seleniumdeficiencyduringpregnancyinmiceimpairsexerciseperformanceandmetabolicfunctioninadultoffspring AT anthonyvperkins seleniumdeficiencyduringpregnancyinmiceimpairsexerciseperformanceandmetabolicfunctioninadultoffspring AT jamessmcuffe seleniumdeficiencyduringpregnancyinmiceimpairsexerciseperformanceandmetabolicfunctioninadultoffspring |