A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma
Abstract Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunotherapy have failed in pancreatic cancer. Understanding the underlying mechanism th...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12916-020-01620-y |
| _version_ | 1818573883555446784 |
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| author | Courtney W. Houchen Min Li |
| author_facet | Courtney W. Houchen Min Li |
| author_sort | Courtney W. Houchen |
| collection | DOAJ |
| description | Abstract Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunotherapy have failed in pancreatic cancer. Understanding the underlying mechanism that drives immune evasion of pancreatic cancer is critical for overcoming resistance to therapy. Recently, Dr. He Ren and colleagues proposed a novel concept that a subset of epithelial cells in pancreatic cancer mimics the phenotype and function of regulatory T cells, named as “quasi-regulatory T cells.” These cells contribute to enhanced immune evasion, angiogenesis, and metastasis of pancreatic cancer, thus providing potential therapeutic targets to improve the sensitivity of immunotherapy for this devastating disease. This ground-breaking concept will advance our understanding on the immune evasion of pancreatic cancer and chart novel paths towards the development of personalized treatment for pancreatic cancer. |
| first_indexed | 2024-12-15T00:18:51Z |
| format | Article |
| id | doaj.art-e6058086f37944d99631752c89ca2353 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-15T00:18:51Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-e6058086f37944d99631752c89ca23532022-12-21T22:42:22ZengBMCBMC Medicine1741-70152020-06-011811410.1186/s12916-020-01620-yA subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinomaCourtney W. Houchen0Min Li1Department of Medicine, The University of Oklahoma Health Sciences CenterDepartment of Medicine, The University of Oklahoma Health Sciences CenterAbstract Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunotherapy have failed in pancreatic cancer. Understanding the underlying mechanism that drives immune evasion of pancreatic cancer is critical for overcoming resistance to therapy. Recently, Dr. He Ren and colleagues proposed a novel concept that a subset of epithelial cells in pancreatic cancer mimics the phenotype and function of regulatory T cells, named as “quasi-regulatory T cells.” These cells contribute to enhanced immune evasion, angiogenesis, and metastasis of pancreatic cancer, thus providing potential therapeutic targets to improve the sensitivity of immunotherapy for this devastating disease. This ground-breaking concept will advance our understanding on the immune evasion of pancreatic cancer and chart novel paths towards the development of personalized treatment for pancreatic cancer.http://link.springer.com/article/10.1186/s12916-020-01620-yPancreatic cancerEpithelial cellsRegulatory T cellsImmune evasion |
| spellingShingle | Courtney W. Houchen Min Li A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma BMC Medicine Pancreatic cancer Epithelial cells Regulatory T cells Immune evasion |
| title | A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| title_full | A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| title_fullStr | A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| title_full_unstemmed | A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| title_short | A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| title_sort | subset of epithelial cells mimics regulatory t cells and contributes to immune evasion during development of pancreatic adenocarcinoma |
| topic | Pancreatic cancer Epithelial cells Regulatory T cells Immune evasion |
| url | http://link.springer.com/article/10.1186/s12916-020-01620-y |
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