Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

<p>Abstract</p> <p>Background</p> <p>uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion. Previous studies from our lab have also shown that uPA/uPAR down regulation inhibits cancer cell in...

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Bibliographic Details
Main Authors: Gujrati Meena, Dinh Dzung H, Gondi Christopher S, Raghu Hari, Rao Jasti S
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Molecular Cancer
Subjects:
uPA/uPAR
invasion
glioblastoma
Notch 1 receptor
Online Access:http://www.molecular-cancer.com/content/10/1/130

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