Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage)
Aim. To assess the characteristics of the course of coronavirus infection COVID-19 and to determine the risk factors for adverse events in patients of the regional hematological center. Materials and methods. As part of an observational prospective cohort study, data from 144 medical records of p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2023-09-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/96601/pdf |
| _version_ | 1797634691427205120 |
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| author | Angelina V. Talko Vera A. Nevzorova Vitaliy S. Dubov Nikita S. Muzychenko Eldar R. Gurbanov Sergei K. Dubov Svetlana N. Beniova Anna I. Simakova |
| author_facet | Angelina V. Talko Vera A. Nevzorova Vitaliy S. Dubov Nikita S. Muzychenko Eldar R. Gurbanov Sergei K. Dubov Svetlana N. Beniova Anna I. Simakova |
| author_sort | Angelina V. Talko |
| collection | DOAJ |
| description | Aim. To assess the characteristics of the course of coronavirus infection COVID-19 and to determine the risk factors for adverse events in patients of the regional hematological center.
Materials and methods. As part of an observational prospective cohort study, data from 144 medical records of patients in Primorsky Krai with hematological diseases and COVID-19 were analyzed. The data of the developed standardized questionnaire of the CHRONOS19 study were used. The primary endpoint (adverse outcome) was a composite point that included mortality from any cause during the observation period, development of acute respiratory distress syndrome, hospitalization in the intensive care unit, and the need for mechanical ventilation.
Results. A study of the features of the course of COVID-19 in hematological patients showed an increase in the number of adverse events in patients with neoplastic blood diseases, especially in chronic lymphoproliferative diseases and acute myeloid leukemia. Significant predictors of an unfavorable course of COVID-19 include a refractory/recurrent variant of the course of a blood tumor, glucocorticoid therapy as part of the protocol for the treatment of the underlying disease, stage 34 lung damage according to computerised tomography scans at the onset of COVID-19, and the presence of diabetes mellitus.
Conclusion. Predictors of an unfavorable course of COVID-19 in hematological patients have been identified. Hematological patients in the context of the COVID-19 pandemic require a coordinated interdisciplinary approach involving hematologists and therapists, careful monitoring of clinical and laboratory parameters to reduce the risk of adverse events. |
| first_indexed | 2024-03-11T12:11:12Z |
| format | Article |
| id | doaj.art-e606f849cd584b9f8f573fa6adb3c0bb |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-03-11T12:11:12Z |
| publishDate | 2023-09-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-e606f849cd584b9f8f573fa6adb3c0bb2023-11-07T14:01:32Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422023-09-0195753754210.26442/00403660.2023.07.20227978317Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage)Angelina V. Talko0https://orcid.org/0000-0002-6896-7248Vera A. Nevzorova1https://orcid.org/0000-0002-0117-0349Vitaliy S. Dubov2https://orcid.org/0000-0001-9105-6568Nikita S. Muzychenko3https://orcid.org/0000-0002-0928-1369Eldar R. Gurbanov4https://orcid.org/0000-0002-5057-2627Sergei K. Dubov5https://orcid.org/0000-0003-0511-4990Svetlana N. Beniova6https://orcid.org/0000-0002-8099-1267Anna I. Simakova7https://orcid.org/0000-0002-3334-4673Regional Clinical Hospital №2Pacific State Medical UniversityRegional Clinical Hospital №2Pacific State Medical UniversityPacific State Medical UniversityRegional Clinical Hospital №2Regional Clinical Hospital №2Pacific State Medical UniversityAim. To assess the characteristics of the course of coronavirus infection COVID-19 and to determine the risk factors for adverse events in patients of the regional hematological center. Materials and methods. As part of an observational prospective cohort study, data from 144 medical records of patients in Primorsky Krai with hematological diseases and COVID-19 were analyzed. The data of the developed standardized questionnaire of the CHRONOS19 study were used. The primary endpoint (adverse outcome) was a composite point that included mortality from any cause during the observation period, development of acute respiratory distress syndrome, hospitalization in the intensive care unit, and the need for mechanical ventilation. Results. A study of the features of the course of COVID-19 in hematological patients showed an increase in the number of adverse events in patients with neoplastic blood diseases, especially in chronic lymphoproliferative diseases and acute myeloid leukemia. Significant predictors of an unfavorable course of COVID-19 include a refractory/recurrent variant of the course of a blood tumor, glucocorticoid therapy as part of the protocol for the treatment of the underlying disease, stage 34 lung damage according to computerised tomography scans at the onset of COVID-19, and the presence of diabetes mellitus. Conclusion. Predictors of an unfavorable course of COVID-19 in hematological patients have been identified. Hematological patients in the context of the COVID-19 pandemic require a coordinated interdisciplinary approach involving hematologists and therapists, careful monitoring of clinical and laboratory parameters to reduce the risk of adverse events.https://ter-arkhiv.ru/0040-3660/article/viewFile/96601/pdfсoronavirus infectionhematological diseasesneoplastic diseasesrisk factorsunfavorable outcomecomorbidities |
| spellingShingle | Angelina V. Talko Vera A. Nevzorova Vitaliy S. Dubov Nikita S. Muzychenko Eldar R. Gurbanov Sergei K. Dubov Svetlana N. Beniova Anna I. Simakova Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) Терапевтический архив сoronavirus infection hematological diseases neoplastic diseases risk factors unfavorable outcome comorbidities |
| title | Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) |
| title_full | Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) |
| title_fullStr | Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) |
| title_full_unstemmed | Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) |
| title_short | Features of the course and adverse events risk of coronavirus infection COVID-19 in hematological diseases (data from the CHRONOS19 register for the Primorsky Territory, intermediate stage) |
| title_sort | features of the course and adverse events risk of coronavirus infection covid 19 in hematological diseases data from the chronos19 register for the primorsky territory intermediate stage |
| topic | сoronavirus infection hematological diseases neoplastic diseases risk factors unfavorable outcome comorbidities |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/96601/pdf |
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