Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis
Patients with schizophrenia spectrum disorders show disturbances in self-referential processing and associated neural circuits including the default mode network (DMN). These disturbances may precede the onset of psychosis and may underlie early social and emotional problems. In this study, we exami...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.613142/full |
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| author | Guusje Collin Guusje Collin Guusje Collin Clemens C. C. Bauer Clemens C. C. Bauer Sheeba Arnold Anteraper Sheeba Arnold Anteraper John D. E. Gabrieli Elena Molokotos Raquelle Mesholam-Gately Heidi W. Thermenos Larry J. Seidman Matcheri S. Keshavan Martha E. Shenton Susan Whitfield-Gabrieli Susan Whitfield-Gabrieli |
| author_facet | Guusje Collin Guusje Collin Guusje Collin Clemens C. C. Bauer Clemens C. C. Bauer Sheeba Arnold Anteraper Sheeba Arnold Anteraper John D. E. Gabrieli Elena Molokotos Raquelle Mesholam-Gately Heidi W. Thermenos Larry J. Seidman Matcheri S. Keshavan Martha E. Shenton Susan Whitfield-Gabrieli Susan Whitfield-Gabrieli |
| author_sort | Guusje Collin |
| collection | DOAJ |
| description | Patients with schizophrenia spectrum disorders show disturbances in self-referential processing and associated neural circuits including the default mode network (DMN). These disturbances may precede the onset of psychosis and may underlie early social and emotional problems. In this study, we examined self-referential processing in a group of children (7–12 years) at familial high risk (FHR) for psychosis (N = 17), compared to an age and sex-matched group of healthy control (HC) children (N = 20). The participants were presented with a list of adjectives and asked to indicate whether or not the adjectives described them (self-reference condition) and whether the adjectives described a good or bad trait (semantic condition). Three participants were excluded due to chance-level performance on the semantic task, leaving N = 15 FHR and N = 19 HC for final analysis. Functional MRI (fMRI) was used to measure brain activation during self-referential vs. semantic processing. Internalizing and externalizing problems were assessed with the Child Behavior Checklist (CBCL). Evaluating main effects of task (self > semantic) showed activation of medial prefrontal cortex in HC and precuneus/posterior cingulate cortex (PCC) in FHR. Group-comparison yielded significant results for the FHR > HC contrast, showing two clusters of hyperactivation in precuneus/ PCC (p = 0.004) and anterior cerebellum / temporo-occipital cortex (p = 0.009). Greater precuneus/PCC activation was found to correlate with greater CBCL internalizing (r = 0.60, p = 0.032) and total (r = 0.69, p = 0.009) problems. In all, this study shows hyperactivity of posterior DMN during self-referential processing in pre-adolescent FHR children. This finding posits DMN-related disturbances in self-processing as a developmental brain abnormality associated with familial risk factors that predates not just psychosis, but also the prodromal stage. Moreover, our results suggest that early disturbances in self-referential processing may be related to internalizing problems in at-risk children. |
| first_indexed | 2024-12-22T17:03:08Z |
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| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T17:03:08Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-e6081a4d56f4493ca8a12be69c6fd2222022-12-21T18:19:18ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-02-011210.3389/fpsyt.2021.613142613142Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for PsychosisGuusje Collin0Guusje Collin1Guusje Collin2Clemens C. C. Bauer3Clemens C. C. Bauer4Sheeba Arnold Anteraper5Sheeba Arnold Anteraper6John D. E. Gabrieli7Elena Molokotos8Raquelle Mesholam-Gately9Heidi W. Thermenos10Larry J. Seidman11Matcheri S. Keshavan12Martha E. Shenton13Susan Whitfield-Gabrieli14Susan Whitfield-Gabrieli15Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, NetherlandsDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Psychology, Northeastern University, Boston, MA, United StatesDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Psychology, Northeastern University, Boston, MA, United StatesDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Psychology, Suffolk University, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United StatesDepartment of Psychology, Northeastern University, Boston, MA, United StatesPatients with schizophrenia spectrum disorders show disturbances in self-referential processing and associated neural circuits including the default mode network (DMN). These disturbances may precede the onset of psychosis and may underlie early social and emotional problems. In this study, we examined self-referential processing in a group of children (7–12 years) at familial high risk (FHR) for psychosis (N = 17), compared to an age and sex-matched group of healthy control (HC) children (N = 20). The participants were presented with a list of adjectives and asked to indicate whether or not the adjectives described them (self-reference condition) and whether the adjectives described a good or bad trait (semantic condition). Three participants were excluded due to chance-level performance on the semantic task, leaving N = 15 FHR and N = 19 HC for final analysis. Functional MRI (fMRI) was used to measure brain activation during self-referential vs. semantic processing. Internalizing and externalizing problems were assessed with the Child Behavior Checklist (CBCL). Evaluating main effects of task (self > semantic) showed activation of medial prefrontal cortex in HC and precuneus/posterior cingulate cortex (PCC) in FHR. Group-comparison yielded significant results for the FHR > HC contrast, showing two clusters of hyperactivation in precuneus/ PCC (p = 0.004) and anterior cerebellum / temporo-occipital cortex (p = 0.009). Greater precuneus/PCC activation was found to correlate with greater CBCL internalizing (r = 0.60, p = 0.032) and total (r = 0.69, p = 0.009) problems. In all, this study shows hyperactivity of posterior DMN during self-referential processing in pre-adolescent FHR children. This finding posits DMN-related disturbances in self-processing as a developmental brain abnormality associated with familial risk factors that predates not just psychosis, but also the prodromal stage. Moreover, our results suggest that early disturbances in self-referential processing may be related to internalizing problems in at-risk children.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.613142/fullschizophreniaself-referential processingdefault mode networkfamilial high-riskpsychosis |
| spellingShingle | Guusje Collin Guusje Collin Guusje Collin Clemens C. C. Bauer Clemens C. C. Bauer Sheeba Arnold Anteraper Sheeba Arnold Anteraper John D. E. Gabrieli Elena Molokotos Raquelle Mesholam-Gately Heidi W. Thermenos Larry J. Seidman Matcheri S. Keshavan Martha E. Shenton Susan Whitfield-Gabrieli Susan Whitfield-Gabrieli Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis Frontiers in Psychiatry schizophrenia self-referential processing default mode network familial high-risk psychosis |
| title | Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis |
| title_full | Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis |
| title_fullStr | Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis |
| title_full_unstemmed | Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis |
| title_short | Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis |
| title_sort | hyperactivation of posterior default mode network during self referential processing in children at familial high risk for psychosis |
| topic | schizophrenia self-referential processing default mode network familial high-risk psychosis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.613142/full |
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