254 A systems genomics approach to identify novel drug targets of Ewing sarcoma through ancestry-informed human iPSC modeling

254 A systems genomics approach to identify novel drug targets of Ewing sarcoma through ancestry-informed human iPSC modeling

OBJECTIVES/GOALS: We leverage the disparate incidence of Ewing sarcoma (ES) between European (EUR) and African (AFR) ancestry to study ES tumorigenesis in iPSC-derived cells from donors with a range of AFR ancestry via functional / molecular profiling. Integrated multi-omics analysis furthers explor...

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Bibliographic Details
Main Authors: Rachel M Moss, Kelsie Becklin, Lauren J Mills, Branden S Moriarity, Beau R Webber, Logan G Spector
Format: Article
Language:English
Published: Cambridge University Press 2023-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866123003199/type/journal_article

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