Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery
Objective To compare the sedative effect of different regimens of dexmedetomidine in day-case ophthalmic surgery. Methods Fifty patients, ASA Ⅰ-Ⅱ, who underwent elective ophthalmic surgery, were randomly divided into two groups with 25 in each: The dexmedetomidine(group A) and dexmedetomidine midazo...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-07-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1108.pdf |
| _version_ | 1827390689664565248 |
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| author | YUE Jian-ying, LI Ming, XI Chun-hua |
| author_facet | YUE Jian-ying, LI Ming, XI Chun-hua |
| author_sort | YUE Jian-ying, LI Ming, XI Chun-hua |
| collection | DOAJ |
| description | Objective To compare the sedative effect of different regimens of dexmedetomidine in day-case ophthalmic surgery. Methods Fifty patients, ASA Ⅰ-Ⅱ, who underwent elective ophthalmic surgery, were randomly divided into two groups with 25 in each: The dexmedetomidine(group A) and dexmedetomidine midazolam plus sufentanil (group B). In group A, the loading dose of dexmedetomidine was 0.7 μg/kg, followed by 0.5 μg/(kg·h) dexmedetomidine. In group B, the loading dose was midazolam 1.5 mg and sufentanil 5 μg, followed by 0.5 μg/(kg·h) dexmedetomidine. Intra-operative heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS), oxygen saturation (SPO2) and Ramsay scores, Aldrete score, satisfaction score of patient and surgeon were recorded. Results At T2, T4-T6 time points, the Ramsay scores of group B were lower than that of group A (P＜0.05). The MAP was lower in group B than group A at T3-T7 time points; The HR was higher(P＜0.05) in group B than group A at T2 and T3 time points. Patient satisfaction was significant different between the two groups, the IOWA scores of group B was higher than that of group A(P＜0.05).There were no significant differences between the two groups in BIS, SPO2 and surgeon satisfaction. Conclusions The combination of dexmedetomidine midazolam plus sufentanyl appears to have more advantages in day-case ophthalmic surgery regarding hemodynamic stability, sedation effect and patient satisfaction. |
| first_indexed | 2024-03-08T16:56:21Z |
| format | Article |
| id | doaj.art-e60e20ffc0f34c96bc9966f61e0bdb91 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:56:21Z |
| publishDate | 2022-07-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-e60e20ffc0f34c96bc9966f61e0bdb912024-01-05T02:35:59ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-07-014271108111210.16352/j.issn.1001-6325.2022.07.1108Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgeryYUE Jian-ying, LI Ming, XI Chun-hua0Department of Anesthesiology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,ChinaObjective To compare the sedative effect of different regimens of dexmedetomidine in day-case ophthalmic surgery. Methods Fifty patients, ASA Ⅰ-Ⅱ, who underwent elective ophthalmic surgery, were randomly divided into two groups with 25 in each: The dexmedetomidine(group A) and dexmedetomidine midazolam plus sufentanil (group B). In group A, the loading dose of dexmedetomidine was 0.7 μg/kg, followed by 0.5 μg/(kg·h) dexmedetomidine. In group B, the loading dose was midazolam 1.5 mg and sufentanil 5 μg, followed by 0.5 μg/(kg·h) dexmedetomidine. Intra-operative heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS), oxygen saturation (SPO2) and Ramsay scores, Aldrete score, satisfaction score of patient and surgeon were recorded. Results At T2, T4-T6 time points, the Ramsay scores of group B were lower than that of group A (P＜0.05). The MAP was lower in group B than group A at T3-T7 time points; The HR was higher(P＜0.05) in group B than group A at T2 and T3 time points. Patient satisfaction was significant different between the two groups, the IOWA scores of group B was higher than that of group A(P＜0.05).There were no significant differences between the two groups in BIS, SPO2 and surgeon satisfaction. Conclusions The combination of dexmedetomidine midazolam plus sufentanyl appears to have more advantages in day-case ophthalmic surgery regarding hemodynamic stability, sedation effect and patient satisfaction.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1108.pdfdexmedetomidine|day-case ophthalmic surgery|ramsay score |
| spellingShingle | YUE Jian-ying, LI Ming, XI Chun-hua Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery Jichu yixue yu linchuang dexmedetomidine|day-case ophthalmic surgery|ramsay score |
| title | Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery |
| title_full | Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery |
| title_fullStr | Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery |
| title_full_unstemmed | Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery |
| title_short | Sedation effect of different regimens of dexmedetomidine in day-case ophthalmic surgery |
| title_sort | sedation effect of different regimens of dexmedetomidine in day case ophthalmic surgery |
| topic | dexmedetomidine|day-case ophthalmic surgery|ramsay score |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-7-1108.pdf |
| work_keys_str_mv | AT yuejianyinglimingxichunhua sedationeffectofdifferentregimensofdexmedetomidineindaycaseophthalmicsurgery |