The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent resear...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1074307/full |
| _version_ | 1811178088661254144 |
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| author | Gaofeng Li Qiru Fu Cong Liu Yuxi Peng Jun Gong Shilan Li Yan Huang Haiyuan Zhang |
| author_facet | Gaofeng Li Qiru Fu Cong Liu Yuxi Peng Jun Gong Shilan Li Yan Huang Haiyuan Zhang |
| author_sort | Gaofeng Li |
| collection | DOAJ |
| description | N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked m6A RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of m6A RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of m6A RNA modification in GC. |
| first_indexed | 2024-04-11T06:13:34Z |
| format | Article |
| id | doaj.art-e6131a94b2154b3b9bbd521a39523c2a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T06:13:34Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e6131a94b2154b3b9bbd521a39523c2a2022-12-22T04:41:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10743071074307The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targetsGaofeng Li0Qiru Fu1Cong Liu2Yuxi Peng3Jun Gong4Shilan Li5Yan Huang6Haiyuan Zhang7School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, ChinaSchool of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, ChinaEditorial Department of Journal of Hubei University of Science and Technology, Xianning, Hubei, ChinaSchool of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, ChinaDepartment of Abdominal and Pelvic Medical Oncology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, ChinaSchool of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, ChinaDepartment of Clinical Laboratory, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, ChinaSchool of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, ChinaN6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked m6A RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of m6A RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of m6A RNA modification in GC.https://www.frontiersin.org/articles/10.3389/fonc.2022.1074307/fullm6A RNA modificationgastric cancermRNAncRNARNA methylation |
| spellingShingle | Gaofeng Li Qiru Fu Cong Liu Yuxi Peng Jun Gong Shilan Li Yan Huang Haiyuan Zhang The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets Frontiers in Oncology m6A RNA modification gastric cancer mRNA ncRNA RNA methylation |
| title | The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets |
| title_full | The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets |
| title_fullStr | The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets |
| title_full_unstemmed | The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets |
| title_short | The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets |
| title_sort | regulatory role of n6 methyladenosine rna modification in gastric cancer molecular mechanisms and potential therapeutic targets |
| topic | m6A RNA modification gastric cancer mRNA ncRNA RNA methylation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1074307/full |
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