AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN

AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN

<p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discove...

Full description

Bibliographic Details
Main Authors: Yance Anas, Risha Fillah Fithria, Maulita Cut Nuria, Amprih Martha, Agung Endro Nugroho, Puji Astuti
Format: Article
Language:Indonesian
Published: Universitas Jenderal Achmad Yani 2015-06-01
Series:Kartika: Jurnal Ilmiah Farmasi
Online Access:http://kjif.unjani.ac.id/index.php/kjif/article/view/93
_version_ 1811261960363180032
author Yance Anas
Risha Fillah Fithria
Maulita Cut Nuria
Amprih Martha
Agung Endro Nugroho
Puji Astuti
author_facet Yance Anas
Risha Fillah Fithria
Maulita Cut Nuria
Amprih Martha
Agung Endro Nugroho
Puji Astuti
author_sort Yance Anas
collection DOAJ
description <p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discover new anti-diabetic compounds from natural products in the type-2 diabetes mellitus treatment. </em><em>The purpose of this study was to determine the potential of n-hexane fraction (FHDL) from lenglengan leaf ethanol extract as an antidiabetic in insulin resistance type-2 diabetic </em><em>Rat</em><em>.</em><em> </em><em>Insulin resistance was induced by administration of long-acting insulin (Lantus<sup>®</sup>) 1.80 IU</em><em>.Kg BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> for 14 days. </em><em>Insulin resistance rats tested by using parameter fasting blood glucose (FBG), before and after treatment of long-acting insulin</em><em>. </em><em>Rat has to type-2 diabetes due to insulin resistance when </em><em>FBG </em><em>on day 1</em><em>8</em><em> exceeded </em><em>85 </em><em>mg</em><em>.</em><em>dL</em><em><sup>-1</sup></em><em>. </em><em>Test results show the animal had insulin resistant. </em><em> </em><em>Rat with the insulin resistance is divided into five treatment groups consisting of one group of diabetic control </em><em>(treats with CMC-Na 0.5%, 25 mL</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>), three dose groups of F</em><em>H</em><em>DL (62.5</em><em>; 125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> and a positive control group (treats with metformin 150 mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>)</em><em>.</em><em> FHDL and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> were </em><em>administered once daily for 14 days.</em><em> </em><em>FBG data, before and after treatments were compared. </em><em>FBG assay is using a reagent kit. </em><em>The results showed that FHDL (</em><em>125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> </em><em>and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> are</em><em> shown to have antidiabetic effects in insulin resistance type-2 diabetic rat.</em><em> </em><em>FHDL 250 mg.Kg<sup>-1</sup>.day<sup>-1</sup> antidiabetic effect (25.87%) is equivalent to metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> (21.50) (p&gt;0.05). </em><em>T</em><em>he results of this research can proceed to find the novel antidiabetic compound from the lenglengan leaf ethanol extracts.</em><em></em></p><p><strong><em> </em></strong></p><p><strong><em>Key words   : </em></strong><em>n-Hexane fraction, Lenglengan extract, </em><em>Anti-diabetic</em><em> effects</em><em>,</em><em> I</em><em>nsulin resistance, </em><em>T</em><em>ype-2 diabetic rats.</em><em></em></p><p><strong><em> </em></strong></p>
first_indexed 2024-04-12T19:15:18Z
format Article
id doaj.art-e6145aff94f44d599ad6960786911031
institution Directory Open Access Journal
issn 2354-6565
2502-3438
language Indonesian
last_indexed 2024-04-12T19:15:18Z
publishDate 2015-06-01
publisher Universitas Jenderal Achmad Yani
record_format Article
series Kartika: Jurnal Ilmiah Farmasi
spelling doaj.art-e6145aff94f44d599ad69607869110312022-12-22T03:19:46ZindUniversitas Jenderal Achmad YaniKartika: Jurnal Ilmiah Farmasi2354-65652502-34382015-06-0131202810.26874/kjif.v3i1.9380AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULINYance Anas0Risha Fillah Fithria1Maulita Cut Nuria2Amprih Martha3Agung Endro Nugroho4Puji Astuti5Bagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Biologi Farmasi Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Gadjah Mada YogyakartaBagian Biologi Farmasi Fakultas Farmasi Universitas Gadjah Mada Yogyakarta<p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discover new anti-diabetic compounds from natural products in the type-2 diabetes mellitus treatment. </em><em>The purpose of this study was to determine the potential of n-hexane fraction (FHDL) from lenglengan leaf ethanol extract as an antidiabetic in insulin resistance type-2 diabetic </em><em>Rat</em><em>.</em><em> </em><em>Insulin resistance was induced by administration of long-acting insulin (Lantus<sup>®</sup>) 1.80 IU</em><em>.Kg BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> for 14 days. </em><em>Insulin resistance rats tested by using parameter fasting blood glucose (FBG), before and after treatment of long-acting insulin</em><em>. </em><em>Rat has to type-2 diabetes due to insulin resistance when </em><em>FBG </em><em>on day 1</em><em>8</em><em> exceeded </em><em>85 </em><em>mg</em><em>.</em><em>dL</em><em><sup>-1</sup></em><em>. </em><em>Test results show the animal had insulin resistant. </em><em> </em><em>Rat with the insulin resistance is divided into five treatment groups consisting of one group of diabetic control </em><em>(treats with CMC-Na 0.5%, 25 mL</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>), three dose groups of F</em><em>H</em><em>DL (62.5</em><em>; 125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> and a positive control group (treats with metformin 150 mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>)</em><em>.</em><em> FHDL and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> were </em><em>administered once daily for 14 days.</em><em> </em><em>FBG data, before and after treatments were compared. </em><em>FBG assay is using a reagent kit. </em><em>The results showed that FHDL (</em><em>125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> </em><em>and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> are</em><em> shown to have antidiabetic effects in insulin resistance type-2 diabetic rat.</em><em> </em><em>FHDL 250 mg.Kg<sup>-1</sup>.day<sup>-1</sup> antidiabetic effect (25.87%) is equivalent to metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> (21.50) (p&gt;0.05). </em><em>T</em><em>he results of this research can proceed to find the novel antidiabetic compound from the lenglengan leaf ethanol extracts.</em><em></em></p><p><strong><em> </em></strong></p><p><strong><em>Key words   : </em></strong><em>n-Hexane fraction, Lenglengan extract, </em><em>Anti-diabetic</em><em> effects</em><em>,</em><em> I</em><em>nsulin resistance, </em><em>T</em><em>ype-2 diabetic rats.</em><em></em></p><p><strong><em> </em></strong></p>http://kjif.unjani.ac.id/index.php/kjif/article/view/93
spellingShingle Yance Anas
Risha Fillah Fithria
Maulita Cut Nuria
Amprih Martha
Agung Endro Nugroho
Puji Astuti
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
Kartika: Jurnal Ilmiah Farmasi
title AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
title_full AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
title_fullStr AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
title_full_unstemmed AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
title_short AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
title_sort aktivitas antidiabetes fraksi n heksan ekstrak etanol daun lenglengan leucas lavandulifolia je smith pada tikus dm tipe 2 yang mengalami resistensi insulin
url http://kjif.unjani.ac.id/index.php/kjif/article/view/93
work_keys_str_mv AT yanceanas aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin
AT rishafillahfithria aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin
AT maulitacutnuria aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin
AT amprihmartha aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin
AT agungendronugroho aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin
AT pujiastuti aktivitasantidiabetesfraksinheksanekstraketanoldaunlenglenganleucaslavandulifoliajesmithpadatikusdmtipe2yangmengalamiresistensiinsulin

Similar Items