Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion
Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine the fate and bioactivity of bovine whey proteins post simulated gastrointesti...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618304754 |
| _version_ | 1818596514631516160 |
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| author | Alberto R. Corrochano Elena Arranz Ivano De Noni Milda Stuknytė Anita Ferraretto Phil M. Kelly Vitaly Buckin Linda Giblin |
| author_facet | Alberto R. Corrochano Elena Arranz Ivano De Noni Milda Stuknytė Anita Ferraretto Phil M. Kelly Vitaly Buckin Linda Giblin |
| author_sort | Alberto R. Corrochano |
| collection | DOAJ |
| description | Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine the fate and bioactivity of bovine whey proteins post simulated gastrointestinal digestion (GID). Our results demonstrated that β-lactoglobulin and α-lactalbumin post GID protect human intestinal cells from free radical formation. Post GID, lactoferrin significantly increased the amount of the intracellular antioxidant enzymes superoxide dismutase 1, 2 and thioredoxin. In addition, all whey samples post GID inhibited the activity of the dipeptidyl peptidase IV. However, the conditions of the gut destroyed the ability of whey proteins to act as glucagon-like peptide-1 secretagogues. The peptide profiles of GID whey protein isolate, β-lactoglobulin, α-lactalbumin, bovine serum albumin and lactoferrin revealed several peptides with bioactive potential. |
| first_indexed | 2024-12-16T11:33:07Z |
| format | Article |
| id | doaj.art-e614b55755994ceabc83d669337521f6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T11:33:07Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e614b55755994ceabc83d669337521f62022-12-21T22:33:11ZengElsevierJournal of Functional Foods1756-46462018-10-0149526535Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestionAlberto R. Corrochano0Elena Arranz1Ivano De Noni2Milda Stuknytė3Anita Ferraretto4Phil M. Kelly5Vitaly Buckin6Linda Giblin7Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, Ireland; School of Chemistry, University College Dublin, Belfield, Dublin 4 D04 V1W8, IrelandTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, IrelandDipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DeFENS), Università degli Studi di Milano, via G. Celoria 2, Milan 20133, ItalyDipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DeFENS), Università degli Studi di Milano, via G. Celoria 2, Milan 20133, ItalyDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, LITA, Segrate 20090, ItalyTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, IrelandSchool of Chemistry, University College Dublin, Belfield, Dublin 4 D04 V1W8, IrelandTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, Ireland; Corresponding author.Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine the fate and bioactivity of bovine whey proteins post simulated gastrointestinal digestion (GID). Our results demonstrated that β-lactoglobulin and α-lactalbumin post GID protect human intestinal cells from free radical formation. Post GID, lactoferrin significantly increased the amount of the intracellular antioxidant enzymes superoxide dismutase 1, 2 and thioredoxin. In addition, all whey samples post GID inhibited the activity of the dipeptidyl peptidase IV. However, the conditions of the gut destroyed the ability of whey proteins to act as glucagon-like peptide-1 secretagogues. The peptide profiles of GID whey protein isolate, β-lactoglobulin, α-lactalbumin, bovine serum albumin and lactoferrin revealed several peptides with bioactive potential.http://www.sciencedirect.com/science/article/pii/S1756464618304754Whey proteinIn vitro digestionBioactive peptideGlucagon-like peptide-1Dipeptidyl peptidase IV inhibitorAntioxidant activity |
| spellingShingle | Alberto R. Corrochano Elena Arranz Ivano De Noni Milda Stuknytė Anita Ferraretto Phil M. Kelly Vitaly Buckin Linda Giblin Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion Journal of Functional Foods Whey protein In vitro digestion Bioactive peptide Glucagon-like peptide-1 Dipeptidyl peptidase IV inhibitor Antioxidant activity |
| title | Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| title_full | Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| title_fullStr | Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| title_full_unstemmed | Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| title_short | Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| title_sort | intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion |
| topic | Whey protein In vitro digestion Bioactive peptide Glucagon-like peptide-1 Dipeptidyl peptidase IV inhibitor Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618304754 |
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