Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease

Adult-onset Still’s disease is a complex autoinflammatory disease with a multifactorial etiology. Its presentation is less stereotypical than that of a monogenic autoinflammatory disease and is actually relatively common with few specific signs. To avoid under- or over-prescription of complementary...

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Main Authors: Nicolas Poursac, Itsaso Odriozola, Marie-Elise Truchetet
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/11/8/2232
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author Nicolas Poursac
Itsaso Odriozola
Marie-Elise Truchetet
author_facet Nicolas Poursac
Itsaso Odriozola
Marie-Elise Truchetet
author_sort Nicolas Poursac
collection DOAJ
description Adult-onset Still’s disease is a complex autoinflammatory disease with a multifactorial etiology. Its presentation is less stereotypical than that of a monogenic autoinflammatory disease and is actually relatively common with few specific signs. To avoid under- or over-prescription of complementary examinations, it is useful to advance in a structured manner, taking into consideration the actual added value of each supplemental examination. In this review, we detail the different complementary tests used in adult Still’s disease. We consider them from three different angles: positive diagnostic approach, the differential diagnosis, and the screening for complications of the disease. After discussing the various tests at our disposal, we look at the classical diagnostic strategy in order to propose a structured algorithm that can be used in clinical practice. We conclude with the prospects of new complementary examinations, which could in the future modify the management of patients.
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spelling doaj.art-e61579667a9641b383d12cdd3a3ce63d2023-11-30T21:19:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118223210.3390/jcm11082232Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s DiseaseNicolas Poursac0Itsaso Odriozola1Marie-Elise Truchetet2Department of Rheumatology, FHU ACRONIM, University Hospital of Bordeaux, 33000 Bordeaux, FranceDepartment of Rheumatology, FHU ACRONIM, University Hospital of Bordeaux, 33000 Bordeaux, FranceDepartment of Rheumatology, FHU ACRONIM, University Hospital of Bordeaux, 33000 Bordeaux, FranceAdult-onset Still’s disease is a complex autoinflammatory disease with a multifactorial etiology. Its presentation is less stereotypical than that of a monogenic autoinflammatory disease and is actually relatively common with few specific signs. To avoid under- or over-prescription of complementary examinations, it is useful to advance in a structured manner, taking into consideration the actual added value of each supplemental examination. In this review, we detail the different complementary tests used in adult Still’s disease. We consider them from three different angles: positive diagnostic approach, the differential diagnosis, and the screening for complications of the disease. After discussing the various tests at our disposal, we look at the classical diagnostic strategy in order to propose a structured algorithm that can be used in clinical practice. We conclude with the prospects of new complementary examinations, which could in the future modify the management of patients.https://www.mdpi.com/2077-0383/11/8/2232adult-onset Still’s diseasebiological examinationradiological examinations
spellingShingle Nicolas Poursac
Itsaso Odriozola
Marie-Elise Truchetet
Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
Journal of Clinical Medicine
adult-onset Still’s disease
biological examination
radiological examinations
title Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
title_full Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
title_fullStr Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
title_full_unstemmed Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
title_short Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease
title_sort strategy and challenges of paraclinical examinations in adult onset still s disease
topic adult-onset Still’s disease
biological examination
radiological examinations
url https://www.mdpi.com/2077-0383/11/8/2232
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