Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes
Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Immunology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255522000191 |
| _version_ | 1811187234035990528 |
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| author | Arisa Shintani Shoko Fukai Reika Nobusawa Kanako Taniguchi Tomohiro Hatatani Hayato Nagai Tomohiro Sakai Takuji Yoshimura Masayuki Miyasaka Haruko Hayasaka |
| author_facet | Arisa Shintani Shoko Fukai Reika Nobusawa Kanako Taniguchi Tomohiro Hatatani Hayato Nagai Tomohiro Sakai Takuji Yoshimura Masayuki Miyasaka Haruko Hayasaka |
| author_sort | Arisa Shintani |
| collection | DOAJ |
| description | Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1+ and CD34+ endothelial cells is reduced in the lymph nodes of neonatal conventional and vascular-specific Dach1-deficient mice. Dach1-deficient lymph nodes in adult mice demonstrated a lower proportion of PNAd+ cells and lower recruitment of intravenously administered lymphocytes from GFP transgenic mice. These findings suggest that DACH1 promotes the expression of HEV-selective adhesion molecules and mediates lymphocyte trafficking across HEVs into lymph nodes. |
| first_indexed | 2024-04-11T13:58:40Z |
| format | Article |
| id | doaj.art-e6168282692643a9bd971a0c57bc3313 |
| institution | Directory Open Access Journal |
| issn | 2590-2555 |
| language | English |
| last_indexed | 2024-04-11T13:58:40Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Immunology |
| spelling | doaj.art-e6168282692643a9bd971a0c57bc33132022-12-22T04:20:11ZengElsevierCurrent Research in Immunology2590-25552022-01-013175185Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodesArisa Shintani0Shoko Fukai1Reika Nobusawa2Kanako Taniguchi3Tomohiro Hatatani4Hayato Nagai5Tomohiro Sakai6Takuji Yoshimura7Masayuki Miyasaka8Haruko Hayasaka9Faculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, JapanWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, JapanFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, JapanWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, JapanFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, JapanFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, JapanFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, JapanThe Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, JapanWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, JapanFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan; Corresponding author.Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1+ and CD34+ endothelial cells is reduced in the lymph nodes of neonatal conventional and vascular-specific Dach1-deficient mice. Dach1-deficient lymph nodes in adult mice demonstrated a lower proportion of PNAd+ cells and lower recruitment of intravenously administered lymphocytes from GFP transgenic mice. These findings suggest that DACH1 promotes the expression of HEV-selective adhesion molecules and mediates lymphocyte trafficking across HEVs into lymph nodes.http://www.sciencedirect.com/science/article/pii/S2590255522000191LymphocyteLymph nodeEndothelial cellTranscription factorTrafficking |
| spellingShingle | Arisa Shintani Shoko Fukai Reika Nobusawa Kanako Taniguchi Tomohiro Hatatani Hayato Nagai Tomohiro Sakai Takuji Yoshimura Masayuki Miyasaka Haruko Hayasaka Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes Current Research in Immunology Lymphocyte Lymph node Endothelial cell Transcription factor Trafficking |
| title | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| title_full | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| title_fullStr | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| title_full_unstemmed | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| title_short | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| title_sort | dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes |
| topic | Lymphocyte Lymph node Endothelial cell Transcription factor Trafficking |
| url | http://www.sciencedirect.com/science/article/pii/S2590255522000191 |
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