Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs
Prevalence of masticatory parafunctions, such as tooth clenching and grinding, is higher among migraineurs than non-migraineurs, and masticatory dysfunctions may aggravate migraine. Migraine predisposes to cerebrovascular disturbances, possibly due to impaired autonomic vasoregulation, and sensitiza...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.01112/full |
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| author | Nina Zaproudina Nina Zaproudina Antti-Pekka E. Rissanen Antti-Pekka E. Rissanen Jukka A. Lipponen Anu Vierola Anu Vierola Saara M. Rissanen Pasi A. Karjalainen Seppo Soinila Matti Närhi Matti Närhi |
| author_facet | Nina Zaproudina Nina Zaproudina Antti-Pekka E. Rissanen Antti-Pekka E. Rissanen Jukka A. Lipponen Anu Vierola Anu Vierola Saara M. Rissanen Pasi A. Karjalainen Seppo Soinila Matti Närhi Matti Närhi |
| author_sort | Nina Zaproudina |
| collection | DOAJ |
| description | Prevalence of masticatory parafunctions, such as tooth clenching and grinding, is higher among migraineurs than non-migraineurs, and masticatory dysfunctions may aggravate migraine. Migraine predisposes to cerebrovascular disturbances, possibly due to impaired autonomic vasoregulation, and sensitization of the trigeminovascular system. The relationships between clenching, migraine, and cerebral circulation are poorly understood. We used Near-Infrared Spectroscopy to investigate bilateral relative oxy- (%Δ[O2Hb]), deoxy- (%Δ[HHb]), and total (%Δ[tHb]) hemoglobin concentration changes in prefrontal cortex induced by maximal tooth clenching in twelve headache-free migraineurs and fourteen control subjects. From the start of the test, migraineurs showed a greater relative increase in right-side %Δ[HHb] than controls, who showed varying reactions, and right-side increase in %Δ[tHb] was also greater in migraineurs (p < 0.001 and p < 0.05, respectively, time-group interactions, Linear mixed models). With multivariate regression model, migraine predicted the magnitude of maximal blood pressure increases, associated in migraineurs with mood scores and an intensity of both headache and painful signs of temporomandibular disorders (pTMD). Although changes in circulatory parameters predicted maximal NIRS responses, the between-group differences in the right-side NIRS findings remained significant after adjusting them for systolic blood pressure and heart rate. A family history of migraine, reported by all migraineurs and four controls, also predicted maximal increases in both %Δ[HHb] and %Δ[tHb]. Presence of pTMD, revealed in clinical oral examination in eight migraineurs and eight controls, was related to maximal %Δ[HHb] increase only in controls. To conclude, the greater prefrontal right-side increases in cerebral %Δ[HHb] and %Δ[tHb] may reflect disturbance of the tooth clenching-related cerebral (de)oxygenation based on impaired reactivity and abnormal microcirculation processes in migraineurs. This finding may have an impact in migraine pathophysiology and help to explain the deleterious effect of masticatory dysfunctions in migraine patients. However, the role of tooth clenching as a migraine trigger calls for further studies. |
| first_indexed | 2024-12-21T05:37:27Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T05:37:27Z |
| publishDate | 2018-12-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-e617e99ff6634cfeb39f5f3bec236e792022-12-21T19:14:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-12-01910.3389/fneur.2018.01112430154Tooth Clenching Induces Abnormal Cerebrovascular Responses in MigraineursNina Zaproudina0Nina Zaproudina1Antti-Pekka E. Rissanen2Antti-Pekka E. Rissanen3Jukka A. Lipponen4Anu Vierola5Anu Vierola6Saara M. Rissanen7Pasi A. Karjalainen8Seppo Soinila9Matti Närhi10Matti Närhi11Institute of Dentistry, University of Eastern Finland, Kuopio, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandDepartment of Sports and Exercise Medicine, Clinicum, University of Helsinki, Helsinki, FinlandDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandInstitute of Dentistry, University of Eastern Finland, Kuopio, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandDivision of Clinical Neurosciences, General Neurology, Turku University Hospital and Department of Neurology, Turku University Hospital, Turku, FinlandInstitute of Dentistry, University of Eastern Finland, Kuopio, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandPrevalence of masticatory parafunctions, such as tooth clenching and grinding, is higher among migraineurs than non-migraineurs, and masticatory dysfunctions may aggravate migraine. Migraine predisposes to cerebrovascular disturbances, possibly due to impaired autonomic vasoregulation, and sensitization of the trigeminovascular system. The relationships between clenching, migraine, and cerebral circulation are poorly understood. We used Near-Infrared Spectroscopy to investigate bilateral relative oxy- (%Δ[O2Hb]), deoxy- (%Δ[HHb]), and total (%Δ[tHb]) hemoglobin concentration changes in prefrontal cortex induced by maximal tooth clenching in twelve headache-free migraineurs and fourteen control subjects. From the start of the test, migraineurs showed a greater relative increase in right-side %Δ[HHb] than controls, who showed varying reactions, and right-side increase in %Δ[tHb] was also greater in migraineurs (p < 0.001 and p < 0.05, respectively, time-group interactions, Linear mixed models). With multivariate regression model, migraine predicted the magnitude of maximal blood pressure increases, associated in migraineurs with mood scores and an intensity of both headache and painful signs of temporomandibular disorders (pTMD). Although changes in circulatory parameters predicted maximal NIRS responses, the between-group differences in the right-side NIRS findings remained significant after adjusting them for systolic blood pressure and heart rate. A family history of migraine, reported by all migraineurs and four controls, also predicted maximal increases in both %Δ[HHb] and %Δ[tHb]. Presence of pTMD, revealed in clinical oral examination in eight migraineurs and eight controls, was related to maximal %Δ[HHb] increase only in controls. To conclude, the greater prefrontal right-side increases in cerebral %Δ[HHb] and %Δ[tHb] may reflect disturbance of the tooth clenching-related cerebral (de)oxygenation based on impaired reactivity and abnormal microcirculation processes in migraineurs. This finding may have an impact in migraine pathophysiology and help to explain the deleterious effect of masticatory dysfunctions in migraine patients. However, the role of tooth clenching as a migraine trigger calls for further studies.https://www.frontiersin.org/article/10.3389/fneur.2018.01112/fullcerebral blood flowheadacheimagingnear-infrared spectroscopytrigeminovascular system |
| spellingShingle | Nina Zaproudina Nina Zaproudina Antti-Pekka E. Rissanen Antti-Pekka E. Rissanen Jukka A. Lipponen Anu Vierola Anu Vierola Saara M. Rissanen Pasi A. Karjalainen Seppo Soinila Matti Närhi Matti Närhi Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs Frontiers in Neurology cerebral blood flow headache imaging near-infrared spectroscopy trigeminovascular system |
| title | Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs |
| title_full | Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs |
| title_fullStr | Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs |
| title_full_unstemmed | Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs |
| title_short | Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs |
| title_sort | tooth clenching induces abnormal cerebrovascular responses in migraineurs |
| topic | cerebral blood flow headache imaging near-infrared spectroscopy trigeminovascular system |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.01112/full |
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