Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection
Abstract HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes induced by viral infection might play a critical role in virus–host interactions in HI...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-022-00946-3 |
| _version_ | 1818499075382706176 |
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| author | Vaishnavi Sundar Jay P. McLaughlin Thangavel Samikkannu |
| author_facet | Vaishnavi Sundar Jay P. McLaughlin Thangavel Samikkannu |
| author_sort | Vaishnavi Sundar |
| collection | DOAJ |
| description | Abstract HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes induced by viral infection might play a critical role in virus–host interactions in HIV infection. The mitochondrial epigenetic mechanism, predominantly Nt acetylation, holds HIV immunopathogenesis and is vastly unexplored. The challenge is to single out the specific pathological role of NAT changes in HIV-associated neurodegeneration. Therefore, this nano review aims to shine light on Nt acetylation in HIV pathogenesis, which we believe can lead to effective future therapeutic strategies against HIV-associated neurodegeneration. |
| first_indexed | 2024-12-10T20:24:19Z |
| format | Article |
| id | doaj.art-e61ba18bd000456ebe5759a6c7f8db28 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-10T20:24:19Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-e61ba18bd000456ebe5759a6c7f8db282022-12-22T01:34:56ZengBMCMolecular Brain1756-66062022-08-011511410.1186/s13041-022-00946-3Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infectionVaishnavi Sundar0Jay P. McLaughlin1Thangavel Samikkannu2Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M UniversityDepartment of Pharmacodynamics, College of Pharmacy, University of FloridaDepartment of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M UniversityAbstract HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes induced by viral infection might play a critical role in virus–host interactions in HIV infection. The mitochondrial epigenetic mechanism, predominantly Nt acetylation, holds HIV immunopathogenesis and is vastly unexplored. The challenge is to single out the specific pathological role of NAT changes in HIV-associated neurodegeneration. Therefore, this nano review aims to shine light on Nt acetylation in HIV pathogenesis, which we believe can lead to effective future therapeutic strategies against HIV-associated neurodegeneration.https://doi.org/10.1186/s13041-022-00946-3EpigeneticsNt-acetylationNt acetyltransferaseHIVNeurodegeneration |
| spellingShingle | Vaishnavi Sundar Jay P. McLaughlin Thangavel Samikkannu Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection Molecular Brain Epigenetics Nt-acetylation Nt acetyltransferase HIV Neurodegeneration |
| title | Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection |
| title_full | Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection |
| title_fullStr | Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection |
| title_full_unstemmed | Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection |
| title_short | Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection |
| title_sort | epigenetic signature of n terminal acetyltransferases a probable mediator of immune and neuropathogenesis in hiv infection |
| topic | Epigenetics Nt-acetylation Nt acetyltransferase HIV Neurodegeneration |
| url | https://doi.org/10.1186/s13041-022-00946-3 |
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