ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species
Combatting the rapidly growing threat of antimicrobial resistance and reducing prevalence and transmission of ESKAPEE pathogens in healthcare settings requires innovative strategies, one of which is displacing these pathogens using beneficial microorganisms. Our review comprehensively examines the e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/5/871 |
| _version_ | 1797601368453677056 |
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| author | Claudio Neidhöfer Kamni Rathore Marijo Parčina Martin A. Sieber |
| author_facet | Claudio Neidhöfer Kamni Rathore Marijo Parčina Martin A. Sieber |
| author_sort | Claudio Neidhöfer |
| collection | DOAJ |
| description | Combatting the rapidly growing threat of antimicrobial resistance and reducing prevalence and transmission of ESKAPEE pathogens in healthcare settings requires innovative strategies, one of which is displacing these pathogens using beneficial microorganisms. Our review comprehensively examines the evidence of probiotic bacteria displacing ESKAPEE pathogens, with a focus on inanimate surfaces. A systematic search was conducted using the PubMed and Web of Science databases on 21 December 2021, and 143 studies were identified examining the effects of <i>Lactobacillaceae</i> and <i>Bacillus</i> spp. cells and products on the growth, colonization, and survival of ESKAPEE pathogens. While the diversity of study methods limits evidence analysis, results presented by narrative synthesis demonstrate that several species have the potential as cells or their products or supernatants to displace nosocomial infection-causing organisms in a variety of in vitro and in vivo settings. Our review aims to aid the development of new promising approaches to control pathogen biofilms in medical settings by informing researchers and policymakers about the potential of probiotics to combat nosocomial infections. More targeted studies are needed to assess safety and efficacy of different probiotic formulations, followed by large-scale studies to assess utility in infection control and medical practice. |
| first_indexed | 2024-03-11T04:00:11Z |
| format | Article |
| id | doaj.art-e61caadac4724e3da7c548967ad2a9d5 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T04:00:11Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e61caadac4724e3da7c548967ad2a9d52023-11-18T00:12:31ZengMDPI AGAntibiotics2079-63822023-05-0112587110.3390/antibiotics12050871ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> speciesClaudio Neidhöfer0Kamni Rathore1Marijo Parčina2Martin A. Sieber3Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, GermanyInstitute for Functional Gene Analytics, Bonn-Rhein-Sieg University of Applied Sciences, 53757 Sankt Augustin, GermanyCombatting the rapidly growing threat of antimicrobial resistance and reducing prevalence and transmission of ESKAPEE pathogens in healthcare settings requires innovative strategies, one of which is displacing these pathogens using beneficial microorganisms. Our review comprehensively examines the evidence of probiotic bacteria displacing ESKAPEE pathogens, with a focus on inanimate surfaces. A systematic search was conducted using the PubMed and Web of Science databases on 21 December 2021, and 143 studies were identified examining the effects of <i>Lactobacillaceae</i> and <i>Bacillus</i> spp. cells and products on the growth, colonization, and survival of ESKAPEE pathogens. While the diversity of study methods limits evidence analysis, results presented by narrative synthesis demonstrate that several species have the potential as cells or their products or supernatants to displace nosocomial infection-causing organisms in a variety of in vitro and in vivo settings. Our review aims to aid the development of new promising approaches to control pathogen biofilms in medical settings by informing researchers and policymakers about the potential of probiotics to combat nosocomial infections. More targeted studies are needed to assess safety and efficacy of different probiotic formulations, followed by large-scale studies to assess utility in infection control and medical practice.https://www.mdpi.com/2079-6382/12/5/871surface sanitizationhealthcare-associated infections (HAI)biofilm-related infectionsbiofilm removalinfection preventionpathogen control |
| spellingShingle | Claudio Neidhöfer Kamni Rathore Marijo Parčina Martin A. Sieber ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species Antibiotics surface sanitization healthcare-associated infections (HAI) biofilm-related infections biofilm removal infection prevention pathogen control |
| title | ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species |
| title_full | ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species |
| title_fullStr | ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species |
| title_full_unstemmed | ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species |
| title_short | ESKAPEE Pathogen Biofilm Control on Surfaces with Probiotic <i>Lactobacillaceae</i> and <i>Bacillus</i> species |
| title_sort | eskapee pathogen biofilm control on surfaces with probiotic i lactobacillaceae i and i bacillus i species |
| topic | surface sanitization healthcare-associated infections (HAI) biofilm-related infections biofilm removal infection prevention pathogen control |
| url | https://www.mdpi.com/2079-6382/12/5/871 |
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