Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective
The separation and detection of flavonoids from various natural products have attracted increasing attention in the field of natural product research and development. Depending on the high specificity of molecularly imprinted polymers (MIPs), MIPs are proposed as efficient adsorbents for the selecti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7355 |
| _version_ | 1797467140063756288 |
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| author | Yurou Yang Xiantao Shen |
| author_facet | Yurou Yang Xiantao Shen |
| author_sort | Yurou Yang |
| collection | DOAJ |
| description | The separation and detection of flavonoids from various natural products have attracted increasing attention in the field of natural product research and development. Depending on the high specificity of molecularly imprinted polymers (MIPs), MIPs are proposed as efficient adsorbents for the selective extraction and separation of flavonoids from complex samples. At present, a comprehensive review article to summarize the separation and purification of flavonoids using molecular imprinting, and the employment of MIP-based sensors for the detection of flavonoids is still lacking. Here, we reviewed the general preparation methods of MIPs towards flavonoids, including bulk polymerization, precipitation polymerization, surface imprinting and emulsion polymerization. Additionally, a variety of applications of MIPs towards flavonoids are summarized, such as the different forms of MIP-based solid phase extraction (SPE) for the separation of flavonoids, and the MIP-based sensors for the detection of flavonoids. Finally, we discussed the advantages and disadvantages of the current synthetic methods for preparing MIPs of flavonoids and prospected the approaches for detecting flavonoids in the future. The purpose of this review is to provide helpful suggestions for the novel preparation methods of MIPs for the extraction of flavonoids and emerging applications of MIPs for the detection of flavonoids from natural products and biological samples. |
| first_indexed | 2024-03-09T18:48:26Z |
| format | Article |
| id | doaj.art-e61cf97a2cfa4ab9a8fcdb31b2e84cfd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:26Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e61cf97a2cfa4ab9a8fcdb31b2e84cfd2023-11-24T06:02:52ZengMDPI AGMolecules1420-30492022-10-012721735510.3390/molecules27217355Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and PerspectiveYurou Yang0Xiantao Shen1State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road #13, Wuhan 430030, ChinaState Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road #13, Wuhan 430030, ChinaThe separation and detection of flavonoids from various natural products have attracted increasing attention in the field of natural product research and development. Depending on the high specificity of molecularly imprinted polymers (MIPs), MIPs are proposed as efficient adsorbents for the selective extraction and separation of flavonoids from complex samples. At present, a comprehensive review article to summarize the separation and purification of flavonoids using molecular imprinting, and the employment of MIP-based sensors for the detection of flavonoids is still lacking. Here, we reviewed the general preparation methods of MIPs towards flavonoids, including bulk polymerization, precipitation polymerization, surface imprinting and emulsion polymerization. Additionally, a variety of applications of MIPs towards flavonoids are summarized, such as the different forms of MIP-based solid phase extraction (SPE) for the separation of flavonoids, and the MIP-based sensors for the detection of flavonoids. Finally, we discussed the advantages and disadvantages of the current synthetic methods for preparing MIPs of flavonoids and prospected the approaches for detecting flavonoids in the future. The purpose of this review is to provide helpful suggestions for the novel preparation methods of MIPs for the extraction of flavonoids and emerging applications of MIPs for the detection of flavonoids from natural products and biological samples.https://www.mdpi.com/1420-3049/27/21/7355natural productsflavonoidsmolecularly imprinted polymerspreparation methodsapplications |
| spellingShingle | Yurou Yang Xiantao Shen Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective Molecules natural products flavonoids molecularly imprinted polymers preparation methods applications |
| title | Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective |
| title_full | Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective |
| title_fullStr | Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective |
| title_full_unstemmed | Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective |
| title_short | Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective |
| title_sort | preparation and application of molecularly imprinted polymers for flavonoids review and perspective |
| topic | natural products flavonoids molecularly imprinted polymers preparation methods applications |
| url | https://www.mdpi.com/1420-3049/27/21/7355 |
| work_keys_str_mv | AT yurouyang preparationandapplicationofmolecularlyimprintedpolymersforflavonoidsreviewandperspective AT xiantaoshen preparationandapplicationofmolecularlyimprintedpolymersforflavonoidsreviewandperspective |