Role of microRNA-34b-5p in cancer and injury: how does it work?
Abstract MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is dysregulated in various human diseases. It is considered as a tumor-suppressiv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02797-3 |
| _version_ | 1811310759265697792 |
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| author | Xuechun Bai Lianwen Zheng Ying Xu Yan Liang Dandan Li |
| author_facet | Xuechun Bai Lianwen Zheng Ying Xu Yan Liang Dandan Li |
| author_sort | Xuechun Bai |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is dysregulated in various human diseases. It is considered as a tumor-suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53. As a member of the miRNA-34 family, miR-34b-5p serves as a powerful regulator of a suite of cellular activities, including cell growth, multiplication, development, differentiation, and apoptosis. It promotes or represses disease occurrence and progression by participating in some important signaling pathways. This review aimed to provide an overview and update on the differential expression and function of miR-34b-5p in pathophysiologic processes, especially cancer and injury. Additionally, miR-34b-5p‐mediated clinical trials have indicated promising consequences for the therapies of carcinomatosis and injury. With the application of the first tumor-targeted microRNA drug based on miR-34a mimics, it can be inferred that miR-34b-5p may become a crucial factor in the therapy of various diseases. However, further studies on miR-34b-5p should shed light on its involvement in disease pathogenesis and treatment options. |
| first_indexed | 2024-04-13T10:05:50Z |
| format | Article |
| id | doaj.art-e61e0dcf2dc348aa9bfcccf0b1b2bedd |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-13T10:05:50Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-e61e0dcf2dc348aa9bfcccf0b1b2bedd2022-12-22T02:51:07ZengBMCCancer Cell International1475-28672022-12-0122111410.1186/s12935-022-02797-3Role of microRNA-34b-5p in cancer and injury: how does it work?Xuechun Bai0Lianwen Zheng1Ying Xu2Yan Liang3Dandan Li4The Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityAbstract MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is dysregulated in various human diseases. It is considered as a tumor-suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53. As a member of the miRNA-34 family, miR-34b-5p serves as a powerful regulator of a suite of cellular activities, including cell growth, multiplication, development, differentiation, and apoptosis. It promotes or represses disease occurrence and progression by participating in some important signaling pathways. This review aimed to provide an overview and update on the differential expression and function of miR-34b-5p in pathophysiologic processes, especially cancer and injury. Additionally, miR-34b-5p‐mediated clinical trials have indicated promising consequences for the therapies of carcinomatosis and injury. With the application of the first tumor-targeted microRNA drug based on miR-34a mimics, it can be inferred that miR-34b-5p may become a crucial factor in the therapy of various diseases. However, further studies on miR-34b-5p should shed light on its involvement in disease pathogenesis and treatment options.https://doi.org/10.1186/s12935-022-02797-3CancerInjurymicroRNAsmiR-34b-5pPathogenesis |
| spellingShingle | Xuechun Bai Lianwen Zheng Ying Xu Yan Liang Dandan Li Role of microRNA-34b-5p in cancer and injury: how does it work? Cancer Cell International Cancer Injury microRNAs miR-34b-5p Pathogenesis |
| title | Role of microRNA-34b-5p in cancer and injury: how does it work? |
| title_full | Role of microRNA-34b-5p in cancer and injury: how does it work? |
| title_fullStr | Role of microRNA-34b-5p in cancer and injury: how does it work? |
| title_full_unstemmed | Role of microRNA-34b-5p in cancer and injury: how does it work? |
| title_short | Role of microRNA-34b-5p in cancer and injury: how does it work? |
| title_sort | role of microrna 34b 5p in cancer and injury how does it work |
| topic | Cancer Injury microRNAs miR-34b-5p Pathogenesis |
| url | https://doi.org/10.1186/s12935-022-02797-3 |
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