Fecal Supernatants from Patients with Crohn’s Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts

Fecal Supernatants from Patients with Crohn’s Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts

Intestinal macrophages and fibroblasts act as microenvironmental sentinels mediating inflammation and disease progression in Crohn’s disease (CD). We aimed to establish the effects of fecal supernatants (FSs) from patients with CD on macrophage and fibroblast phenotype and function. FS were obtained...

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Detalhes bibliográficos
Principais autores: Frida Gorreja, Mia Bendix, Stephen T. A. Rush, Lujain Maasfeh, Otto Savolainen, Anders Dige, Jorgen Agnholt, Lena Öhman, Maria K. Magnusson
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2023-12-01
coleção:Cells
Assuntos:
fecal metabolites
Crohn’s disease
M2 macrophages
fibrosis
inflammatory bowel disease
Acesso em linha:https://www.mdpi.com/2073-4409/13/1/60

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