Fecal Supernatants from Patients with Crohn’s Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts

Fecal Supernatants from Patients with Crohn’s Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts

Intestinal macrophages and fibroblasts act as microenvironmental sentinels mediating inflammation and disease progression in Crohn’s disease (CD). We aimed to establish the effects of fecal supernatants (FSs) from patients with CD on macrophage and fibroblast phenotype and function. FS were obtained...

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Bibliographic Details
Main Authors: Frida Gorreja, Mia Bendix, Stephen T. A. Rush, Lujain Maasfeh, Otto Savolainen, Anders Dige, Jorgen Agnholt, Lena Öhman, Maria K. Magnusson
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
fecal metabolites
Crohn’s disease
M2 macrophages
fibrosis
inflammatory bowel disease
Online Access:https://www.mdpi.com/2073-4409/13/1/60

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