Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning
Understanding the consistency of pituitary macroadenomas is crucial for neurosurgeons planning surgery. This retrospective study aimed to evaluate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) as non-invasive imaging modalities for predicting the consis...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/5/493 |
| _version_ | 1797264679118045184 |
|---|---|
| author | Rania Mostafa A. Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Sharifa Khalid Alduraibi Alshehri Hanan Hassan Mervat Aboualkheir Ziyad A. Almushayti Alaa K. Alduraibi Mona M. Amer Ahmed M. Abdelkhalik Basha Mona Mohammed Refaat |
| author_facet | Rania Mostafa A. Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Sharifa Khalid Alduraibi Alshehri Hanan Hassan Mervat Aboualkheir Ziyad A. Almushayti Alaa K. Alduraibi Mona M. Amer Ahmed M. Abdelkhalik Basha Mona Mohammed Refaat |
| author_sort | Rania Mostafa A. Hassan |
| collection | DOAJ |
| description | Understanding the consistency of pituitary macroadenomas is crucial for neurosurgeons planning surgery. This retrospective study aimed to evaluate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) as non-invasive imaging modalities for predicting the consistency of pituitary macroadenomas. This could contribute to appropriate surgical planning and therefore reduce the likelihood of incomplete resections. The study included 45 patients with pathologically confirmed pituitary macroadenomas. Conventional MRI sequences, DWIs, ADC maps, and pre- and post-contrast MRIs were performed. Two neuroradiologists assessed all of the images. Neurosurgeons assessed the consistency of the tumor macroscopically, and histopathologists examined it microscopically. The MRI findings were compared with postoperative data. According to the operative data, macroadenomas were divided into the two following categories based on their consistency: aspirable (n = 27) and non-aspirable tumors (n = 18). A statistically significant difference in DWI findings was found when comparing macroadenomas of different consistencies (<i>p</i> < 0.001). Most aspirable macroadenomas (66.7%) were hyperintense according to DWI and hypointense on ADC maps, whereas most non-aspirable macroadenomas (83.3%) were hypointense for DWI and hyperintense on ADC maps. At a cut-off value of 0.63 × 10<sup>−3</sup> mm<sup>2</sup>/s, the ADC showed a sensitivity of 85.7% and a specificity of 75% for the detection of non-aspirable macroadenomas (AUC, 0.946). The study concluded that DWI should be routinely performed in conjunction with ADC measurements in the preoperative evaluation of pituitary macroadenomas. This approach may aid in surgical planning, ensure that appropriate techniques are utilized, and reduce the risk of incomplete resection. |
| first_indexed | 2024-04-25T00:32:44Z |
| format | Article |
| id | doaj.art-e621c57b888e4a0e861f775d0f15bde5 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-25T00:32:44Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e621c57b888e4a0e861f775d0f15bde52024-03-12T16:41:57ZengMDPI AGDiagnostics2075-44182024-02-0114549310.3390/diagnostics14050493Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical PlanningRania Mostafa A. Hassan0Yassir Edrees Almalki1Mohammad Abd Alkhalik Basha2Sharifa Khalid Alduraibi3Alshehri Hanan Hassan4Mervat Aboualkheir5Ziyad A. Almushayti6Alaa K. Alduraibi7Mona M. Amer8Ahmed M. Abdelkhalik Basha9Mona Mohammed Refaat10Department of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptDivision of Radiology, Department of Internal Medicine, Medical College, Najran University, Najran 61441, Saudi ArabiaDepartment of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaInternal Medicine Department, College of Medicine, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Radiology and Medical Imaging, College of Medicine, Taibah University, Madinah 42353, Saudi ArabiaDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaDepartment of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi ArabiaDepartment of Neurology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptFaculty of General Medicine, Saint Petersburg State University, Egypt Branch, Cairo 11646, EgyptDepartment of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, EgyptUnderstanding the consistency of pituitary macroadenomas is crucial for neurosurgeons planning surgery. This retrospective study aimed to evaluate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) as non-invasive imaging modalities for predicting the consistency of pituitary macroadenomas. This could contribute to appropriate surgical planning and therefore reduce the likelihood of incomplete resections. The study included 45 patients with pathologically confirmed pituitary macroadenomas. Conventional MRI sequences, DWIs, ADC maps, and pre- and post-contrast MRIs were performed. Two neuroradiologists assessed all of the images. Neurosurgeons assessed the consistency of the tumor macroscopically, and histopathologists examined it microscopically. The MRI findings were compared with postoperative data. According to the operative data, macroadenomas were divided into the two following categories based on their consistency: aspirable (n = 27) and non-aspirable tumors (n = 18). A statistically significant difference in DWI findings was found when comparing macroadenomas of different consistencies (<i>p</i> < 0.001). Most aspirable macroadenomas (66.7%) were hyperintense according to DWI and hypointense on ADC maps, whereas most non-aspirable macroadenomas (83.3%) were hypointense for DWI and hyperintense on ADC maps. At a cut-off value of 0.63 × 10<sup>−3</sup> mm<sup>2</sup>/s, the ADC showed a sensitivity of 85.7% and a specificity of 75% for the detection of non-aspirable macroadenomas (AUC, 0.946). The study concluded that DWI should be routinely performed in conjunction with ADC measurements in the preoperative evaluation of pituitary macroadenomas. This approach may aid in surgical planning, ensure that appropriate techniques are utilized, and reduce the risk of incomplete resection.https://www.mdpi.com/2075-4418/14/5/493pituitary macroadenomaconsistencyMRIDWIADC |
| spellingShingle | Rania Mostafa A. Hassan Yassir Edrees Almalki Mohammad Abd Alkhalik Basha Sharifa Khalid Alduraibi Alshehri Hanan Hassan Mervat Aboualkheir Ziyad A. Almushayti Alaa K. Alduraibi Mona M. Amer Ahmed M. Abdelkhalik Basha Mona Mohammed Refaat Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning Diagnostics pituitary macroadenoma consistency MRI DWI ADC |
| title | Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning |
| title_full | Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning |
| title_fullStr | Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning |
| title_full_unstemmed | Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning |
| title_short | Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning |
| title_sort | predicting the consistency of pituitary macroadenomas the utility of diffusion weighted imaging and apparent diffusion coefficient measurements for surgical planning |
| topic | pituitary macroadenoma consistency MRI DWI ADC |
| url | https://www.mdpi.com/2075-4418/14/5/493 |
| work_keys_str_mv | AT raniamostafaahassan predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT yassiredreesalmalki predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT mohammadabdalkhalikbasha predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT sharifakhalidalduraibi predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT alshehrihananhassan predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT mervataboualkheir predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT ziyadaalmushayti predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT alaakalduraibi predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT monamamer predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT ahmedmabdelkhalikbasha predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning AT monamohammedrefaat predictingtheconsistencyofpituitarymacroadenomastheutilityofdiffusionweightedimagingandapparentdiffusioncoefficientmeasurementsforsurgicalplanning |