Role of SNAREs in Neurodegenerative Diseases
Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer’s d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/991 |
| _version_ | 1827694383881781248 |
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| author | Azzurra Margiotta |
| author_facet | Azzurra Margiotta |
| author_sort | Azzurra Margiotta |
| collection | DOAJ |
| description | Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described. |
| first_indexed | 2024-03-10T12:03:18Z |
| format | Article |
| id | doaj.art-e622bd05e5024a9bbc8f0647d5c8ac5c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T12:03:18Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e622bd05e5024a9bbc8f0647d5c8ac5c2023-11-21T16:48:17ZengMDPI AGCells2073-44092021-04-0110599110.3390/cells10050991Role of SNAREs in Neurodegenerative DiseasesAzzurra Margiotta0Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech RepublicNeurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described.https://www.mdpi.com/2073-4409/10/5/991SNAREsneurodegenerative diseaseALSParkinson’s diseaseAlzheimer’s diseaseVAMP2 |
| spellingShingle | Azzurra Margiotta Role of SNAREs in Neurodegenerative Diseases Cells SNAREs neurodegenerative disease ALS Parkinson’s disease Alzheimer’s disease VAMP2 |
| title | Role of SNAREs in Neurodegenerative Diseases |
| title_full | Role of SNAREs in Neurodegenerative Diseases |
| title_fullStr | Role of SNAREs in Neurodegenerative Diseases |
| title_full_unstemmed | Role of SNAREs in Neurodegenerative Diseases |
| title_short | Role of SNAREs in Neurodegenerative Diseases |
| title_sort | role of snares in neurodegenerative diseases |
| topic | SNAREs neurodegenerative disease ALS Parkinson’s disease Alzheimer’s disease VAMP2 |
| url | https://www.mdpi.com/2073-4409/10/5/991 |
| work_keys_str_mv | AT azzurramargiotta roleofsnaresinneurodegenerativediseases |