Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities.

Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities.

The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic IL-12 administration can improve responses to tumors, the effects of IL-12-based treatments on DC, in particular hepatic DC, remain incomple...

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Bibliographic Details
Main Authors:	Tim Chan, Timothy C Back, Jeffrey J Subleski, Jonathan M Weiss, John R Ortaldo, Robert H Wiltrout
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3302816?pdf=render

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