The utility of Apc-mutant rats in modeling human colon cancer

The utility of Apc-mutant rats in modeling human colon cancer

Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for investigating the etiology of cancer. Now, recent advances in the manipulation of the rat genome, combined with a growing recognition of the physiological differences between mice and rats, have reignited in...

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Bibliographic Details
Main Authors: Amy A. Irving, Kazuto Yoshimi, Marcia L. Hart, Taybor Parker, Linda Clipson, Madeline R. Ford, Takashi Kuramoto, William F. Dove, James M. Amos-Landgraf
Format: Article
Language:English
Published: The Company of Biologists 2014-11-01
Series:Disease Models & Mechanisms
Subjects:
APC
Allelic series
Animal models
Colorectal cancer
Online Access:http://dmm.biologists.org/content/7/11/1215

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