Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect
Allosteric modulators of metabotropic glutamate 5 receptors (mGlu<sub>5</sub> receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake. However, these conditions are often comorbid and might precipit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/8/183 |
| _version_ | 1817981412211425280 |
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| author | Chelsea R. Kasten Eleanor B. Holmgren Tiffany A. Wills |
| author_facet | Chelsea R. Kasten Eleanor B. Holmgren Tiffany A. Wills |
| author_sort | Chelsea R. Kasten |
| collection | DOAJ |
| description | Allosteric modulators of metabotropic glutamate 5 receptors (mGlu<sub>5</sub> receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake. However, these conditions are often comorbid and might precipitate one another. Acute and protracted ethanol withdrawal can lead to negative affective states. In turn, these states are primary drivers of alcohol relapse, particularly among women. The current review synthesizes preclinical studies that have observed the role of mGlu<sub>5</sub> receptor modulation in negative affective states following ethanol exposure. The primary behavioral assays discussed are ethanol-seeking and intake, development and extinction of ethanol-associated cues and contexts, behavioral despair, and anxiety-like activity. The work done to-date supports mGlu<sub>5</sub> receptor modulation as a promising target for mediating negative affective states to reduce ethanol intake or prevent relapse. Limitations in interpreting these data include the lack of models that use alcohol-dependent animals, limited use of adolescent and female subjects, and a lack of comprehensive evaluations of negative affective-like behavior. |
| first_indexed | 2024-04-13T23:05:37Z |
| format | Article |
| id | doaj.art-e628beb0a10b4a818d5cd3ef19cddc07 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-13T23:05:37Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-e628beb0a10b4a818d5cd3ef19cddc072022-12-22T02:25:41ZengMDPI AGBrain Sciences2076-34252019-07-019818310.3390/brainsci9080183brainsci9080183Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative AffectChelsea R. Kasten0Eleanor B. Holmgren1Tiffany A. Wills2LSU Health Sciences Center—New Orleans, Department of Cell Biology and Anatomy, Medical Education Building, 1901 Perdido Street, Room 6103, New Orleans, LA 70112, USALSU Health Sciences Center—New Orleans, Department of Cell Biology and Anatomy, Medical Education Building, 1901 Perdido Street, Room 6103, New Orleans, LA 70112, USALSU Health Sciences Center—New Orleans, Department of Cell Biology and Anatomy, Medical Education Building, 1901 Perdido Street, Room 6103, New Orleans, LA 70112, USAAllosteric modulators of metabotropic glutamate 5 receptors (mGlu<sub>5</sub> receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake. However, these conditions are often comorbid and might precipitate one another. Acute and protracted ethanol withdrawal can lead to negative affective states. In turn, these states are primary drivers of alcohol relapse, particularly among women. The current review synthesizes preclinical studies that have observed the role of mGlu<sub>5</sub> receptor modulation in negative affective states following ethanol exposure. The primary behavioral assays discussed are ethanol-seeking and intake, development and extinction of ethanol-associated cues and contexts, behavioral despair, and anxiety-like activity. The work done to-date supports mGlu<sub>5</sub> receptor modulation as a promising target for mediating negative affective states to reduce ethanol intake or prevent relapse. Limitations in interpreting these data include the lack of models that use alcohol-dependent animals, limited use of adolescent and female subjects, and a lack of comprehensive evaluations of negative affective-like behavior.https://www.mdpi.com/2076-3425/9/8/183alcoholnegative affectdespairanxietymGlu5sex differencesethanol dependence |
| spellingShingle | Chelsea R. Kasten Eleanor B. Holmgren Tiffany A. Wills Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect Brain Sciences alcohol negative affect despair anxiety mGlu5 sex differences ethanol dependence |
| title | Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect |
| title_full | Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect |
| title_fullStr | Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect |
| title_full_unstemmed | Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect |
| title_short | Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect |
| title_sort | metabotropic glutamate receptor subtype 5 in alcohol induced negative affect |
| topic | alcohol negative affect despair anxiety mGlu5 sex differences ethanol dependence |
| url | https://www.mdpi.com/2076-3425/9/8/183 |
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