Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients
Abstract Background Diversity of risk factors, namely, vitamin D and lipid panel abnormalities, are connected to multiple sclerosis (MS) etiology and may possess an influential role on disease course. In a cross-sectional study, we correlated the demographic, clinical and radiological characteristic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00783-8 |
| _version_ | 1797276713146646528 |
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| author | Mahmoud S. Swelam Azza Abdel Nasser Janet Masoud Rasha Mamdouh Shima Said Mohamed Abdel Hafeez |
| author_facet | Mahmoud S. Swelam Azza Abdel Nasser Janet Masoud Rasha Mamdouh Shima Said Mohamed Abdel Hafeez |
| author_sort | Mahmoud S. Swelam |
| collection | DOAJ |
| description | Abstract Background Diversity of risk factors, namely, vitamin D and lipid panel abnormalities, are connected to multiple sclerosis (MS) etiology and may possess an influential role on disease course. In a cross-sectional study, we correlated the demographic, clinical and radiological characteristics of 111 relapsing–remitting MS (RRMS) patients with their serum levels of vitamin D and lipid profile to evaluate the consequences of their abnormalities on disease activity and/or its progression. Results In the study group, the mean serum level of vitamin D was 18.93 ± 9.85 ng/mL, over 80% had insufficient level ( < 30 ng/mL) and significantly lower in females (P = 0.011). Insufficient vitamin D significantly associated with high relapse frequency (P = 0.005). Measurement the direction of this association showed that each 1 ng/mL increase in vitamin D was correlated with both decrease in annualized relapse rate (ARR) of 0.02 relapse/year (P = 0.017) and with decrease in number of relapses during last 2 years of 0.02 relapse (P = 0.045). Analysis of serum lipid panel showed a direct link between higher levels of TC and LDL to increased total number of relapses (P < 0.001 and 0.003, respectively) and EDSS (P = 0.001 and 0.022), also between higher TG and EDSS (P = 0.001). This link became indirect between HDL and both total number of relapse and EDSS (P = 0.001 and 0.001). Radiologically, positively linked confluent brain lesion to elevated TC and TG levels (P = 0.001 and 0.002, respectively) and cord lesions to elevated TC (P = 0.007). Longer disease duration positively associated with all lipids-related variables. As a direct effect on lipid metabolism, each 1 ng/mL increase in vitamin D was associated with reduction in serum TC of 1.48 mg/dL (P = 0.002) and rise in HDL of 0.35 mg/dL (P = 0.028). Conclusions Management of vitamin D insufficiency may decrease risk of higher ARR and the same for dyslipidemia in reduction of disability and confluent brain T2 lesion. Increasing vitamin D was positively correlated with HDL but negatively with TC. |
| first_indexed | 2024-03-07T15:32:10Z |
| format | Article |
| id | doaj.art-e628f2570f3943dbb0b863ae621fac36 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-07T15:32:10Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-e628f2570f3943dbb0b863ae621fac362024-03-05T16:23:17ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292024-01-0160111010.1186/s41983-023-00783-8Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patientsMahmoud S. Swelam0Azza Abdel Nasser1Janet Masoud2Rasha Mamdouh3Shima Said4Mohamed Abdel Hafeez5Neurology Department, Faculty of Medicine Ain Shams UniversityNeurology Department, Faculty of Medicine Ain Shams UniversityNeurology Department, Faculty of Medicine Ain Shams UniversityClinical Pathology Department, Ain Shams UniversityNeurology Department, Faculty of Medicine Ain Shams UniversityNeurology Department, Faculty of Medicine Ain Shams UniversityAbstract Background Diversity of risk factors, namely, vitamin D and lipid panel abnormalities, are connected to multiple sclerosis (MS) etiology and may possess an influential role on disease course. In a cross-sectional study, we correlated the demographic, clinical and radiological characteristics of 111 relapsing–remitting MS (RRMS) patients with their serum levels of vitamin D and lipid profile to evaluate the consequences of their abnormalities on disease activity and/or its progression. Results In the study group, the mean serum level of vitamin D was 18.93 ± 9.85 ng/mL, over 80% had insufficient level ( < 30 ng/mL) and significantly lower in females (P = 0.011). Insufficient vitamin D significantly associated with high relapse frequency (P = 0.005). Measurement the direction of this association showed that each 1 ng/mL increase in vitamin D was correlated with both decrease in annualized relapse rate (ARR) of 0.02 relapse/year (P = 0.017) and with decrease in number of relapses during last 2 years of 0.02 relapse (P = 0.045). Analysis of serum lipid panel showed a direct link between higher levels of TC and LDL to increased total number of relapses (P < 0.001 and 0.003, respectively) and EDSS (P = 0.001 and 0.022), also between higher TG and EDSS (P = 0.001). This link became indirect between HDL and both total number of relapse and EDSS (P = 0.001 and 0.001). Radiologically, positively linked confluent brain lesion to elevated TC and TG levels (P = 0.001 and 0.002, respectively) and cord lesions to elevated TC (P = 0.007). Longer disease duration positively associated with all lipids-related variables. As a direct effect on lipid metabolism, each 1 ng/mL increase in vitamin D was associated with reduction in serum TC of 1.48 mg/dL (P = 0.002) and rise in HDL of 0.35 mg/dL (P = 0.028). Conclusions Management of vitamin D insufficiency may decrease risk of higher ARR and the same for dyslipidemia in reduction of disability and confluent brain T2 lesion. Increasing vitamin D was positively correlated with HDL but negatively with TC.https://doi.org/10.1186/s41983-023-00783-8Vitamin DLipidsMultiple sclerosisEgyptian |
| spellingShingle | Mahmoud S. Swelam Azza Abdel Nasser Janet Masoud Rasha Mamdouh Shima Said Mohamed Abdel Hafeez Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Vitamin D Lipids Multiple sclerosis Egyptian |
| title | Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients |
| title_full | Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients |
| title_fullStr | Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients |
| title_full_unstemmed | Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients |
| title_short | Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients |
| title_sort | highlights on the link between vitamin d and lipid panel in egyptian multiple sclerosis patients |
| topic | Vitamin D Lipids Multiple sclerosis Egyptian |
| url | https://doi.org/10.1186/s41983-023-00783-8 |
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