GDF15 and Growth Control
Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01712/full |
| _version_ | 1819070720454426624 |
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| author | Paul J. Emmerson Kevin L. Duffin Sudhakar Chintharlapalli Xinle Wu |
| author_facet | Paul J. Emmerson Kevin L. Duffin Sudhakar Chintharlapalli Xinle Wu |
| author_sort | Paul J. Emmerson |
| collection | DOAJ |
| description | Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum levels have a strong association with many diseases, including inflammation, cancer, cardiovascular diseases, and obesity, and potentially serve as reliable predictor of disease progression. A functional role for GDF15 has been suggested in cancer, cardiovascular disease, kidney disease and metabolic disease. However, the knowledge of its pathophysiological function at the molecular level is still limited and requires more investigation. Recent identification of the endogenous receptor for GDF15 may provide additional insight in to its’ molecular mechanisms and relationship to disease states. |
| first_indexed | 2024-12-21T17:10:25Z |
| format | Article |
| id | doaj.art-e62acf91ab594e15a9557fc257b53462 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T17:10:25Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e62acf91ab594e15a9557fc257b534622022-12-21T18:56:25ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-11-01910.3389/fphys.2018.01712411437GDF15 and Growth ControlPaul J. Emmerson0Kevin L. Duffin1Sudhakar Chintharlapalli2Xinle Wu3Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United StatesLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United StatesLilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United StatesLilly China Innovation and Partnerships, Shanghai, ChinaGrowth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor β (TGF-β) superfamily and is widely expressed in multiple mammalian tissues. Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum levels have a strong association with many diseases, including inflammation, cancer, cardiovascular diseases, and obesity, and potentially serve as reliable predictor of disease progression. A functional role for GDF15 has been suggested in cancer, cardiovascular disease, kidney disease and metabolic disease. However, the knowledge of its pathophysiological function at the molecular level is still limited and requires more investigation. Recent identification of the endogenous receptor for GDF15 may provide additional insight in to its’ molecular mechanisms and relationship to disease states.https://www.frontiersin.org/article/10.3389/fphys.2018.01712/fullGDF15TGFβGFRALobesitymetaboliccancer |
| spellingShingle | Paul J. Emmerson Kevin L. Duffin Sudhakar Chintharlapalli Xinle Wu GDF15 and Growth Control Frontiers in Physiology GDF15 TGFβ GFRAL obesity metabolic cancer |
| title | GDF15 and Growth Control |
| title_full | GDF15 and Growth Control |
| title_fullStr | GDF15 and Growth Control |
| title_full_unstemmed | GDF15 and Growth Control |
| title_short | GDF15 and Growth Control |
| title_sort | gdf15 and growth control |
| topic | GDF15 TGFβ GFRAL obesity metabolic cancer |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01712/full |
| work_keys_str_mv | AT pauljemmerson gdf15andgrowthcontrol AT kevinlduffin gdf15andgrowthcontrol AT sudhakarchintharlapalli gdf15andgrowthcontrol AT xinlewu gdf15andgrowthcontrol |