Oxidative Stress in Postmenopausal Women with or without Obesity
Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/8/1137 |
| _version_ | 1797606028689276928 |
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| author | Giulia Leanza Caterina Conte Francesca Cannata Camilla Isgrò Alessandra Piccoli Rocky Strollo Carlo Cosimo Quattrocchi Rocco Papalia Vincenzo Denaro Mauro Maccarrone Nicola Napoli Anna Maria Sardanelli |
| author_facet | Giulia Leanza Caterina Conte Francesca Cannata Camilla Isgrò Alessandra Piccoli Rocky Strollo Carlo Cosimo Quattrocchi Rocco Papalia Vincenzo Denaro Mauro Maccarrone Nicola Napoli Anna Maria Sardanelli |
| author_sort | Giulia Leanza |
| collection | DOAJ |
| description | Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or without obesity. Body composition was assessed via DXA, while lipid peroxidation and total hydroperoxides were measured in patient’s serum samples via thiobarbituric-acid-reactive substances (TBARS) and derivate-reactive oxygen metabolites (d-ROMs) assays, respectively. Accordingly, 31 postmenopausal women were enrolled: 12 with obesity and 19 of normal weight (mean (SD) age 71.0 (5.7) years). Doubled levels of serum markers of oxidative stress were observed in women with obesity in women with obesity compared to those of normal weight (H<sub>2</sub>O<sub>2</sub>: 32.35 (7.3) vs. 18.80 (3.4) mg H<sub>2</sub>O<i><sub>2</sub></i>/dL; malondialdehyde (MDA): 429.6 (138.1) vs. 155.9 (82.4) mM in women with or without obesity, respectively; <i>p</i> < 0.0001 for both). Correlation analysis showed that both markers of oxidative stress increased with an increasing body mass index (BMI), visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. In conclusion, obesity and visceral fat are associated with a greater increase in oxidative stress in postmenopausal women, possibly increasing cardiometabolic and cancer risks. |
| first_indexed | 2024-03-11T05:09:34Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:09:34Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e62df19b875d44fe82afe06f2508b4112023-11-17T18:43:02ZengMDPI AGCells2073-44092023-04-01128113710.3390/cells12081137Oxidative Stress in Postmenopausal Women with or without ObesityGiulia Leanza0Caterina Conte1Francesca Cannata2Camilla Isgrò3Alessandra Piccoli4Rocky Strollo5Carlo Cosimo Quattrocchi6Rocco Papalia7Vincenzo Denaro8Mauro Maccarrone9Nicola Napoli10Anna Maria Sardanelli11Department of Medicine and Surgery, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, ItalyDepartment of Medicine and Surgery, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Medicine and Surgery, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Medicine and Surgery, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Science and Technology for Sustainable Environment and One Health, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, ItalyDepartment of Medicine, Unit of Diagnostic Imaging and Interventional Medicine, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, ItalyDepartment of Medicine, Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, ItalyDepartment of Medicine, Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Via Vetoio snc, 67100 L’Aquila, ItalyDepartment of Medicine and Surgery, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Translational Biomedicine and Neuroscience ‘DiBraiN’, University of Bari “Aldo Moro”, Pi-azza G. Cesare 11, 70124 Bari, ItalyOxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or without obesity. Body composition was assessed via DXA, while lipid peroxidation and total hydroperoxides were measured in patient’s serum samples via thiobarbituric-acid-reactive substances (TBARS) and derivate-reactive oxygen metabolites (d-ROMs) assays, respectively. Accordingly, 31 postmenopausal women were enrolled: 12 with obesity and 19 of normal weight (mean (SD) age 71.0 (5.7) years). Doubled levels of serum markers of oxidative stress were observed in women with obesity in women with obesity compared to those of normal weight (H<sub>2</sub>O<sub>2</sub>: 32.35 (7.3) vs. 18.80 (3.4) mg H<sub>2</sub>O<i><sub>2</sub></i>/dL; malondialdehyde (MDA): 429.6 (138.1) vs. 155.9 (82.4) mM in women with or without obesity, respectively; <i>p</i> < 0.0001 for both). Correlation analysis showed that both markers of oxidative stress increased with an increasing body mass index (BMI), visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. In conclusion, obesity and visceral fat are associated with a greater increase in oxidative stress in postmenopausal women, possibly increasing cardiometabolic and cancer risks.https://www.mdpi.com/2073-4409/12/8/1137obesityoxidative stressmenopausevisceral fatlipid peroxidationoxidative damage |
| spellingShingle | Giulia Leanza Caterina Conte Francesca Cannata Camilla Isgrò Alessandra Piccoli Rocky Strollo Carlo Cosimo Quattrocchi Rocco Papalia Vincenzo Denaro Mauro Maccarrone Nicola Napoli Anna Maria Sardanelli Oxidative Stress in Postmenopausal Women with or without Obesity Cells obesity oxidative stress menopause visceral fat lipid peroxidation oxidative damage |
| title | Oxidative Stress in Postmenopausal Women with or without Obesity |
| title_full | Oxidative Stress in Postmenopausal Women with or without Obesity |
| title_fullStr | Oxidative Stress in Postmenopausal Women with or without Obesity |
| title_full_unstemmed | Oxidative Stress in Postmenopausal Women with or without Obesity |
| title_short | Oxidative Stress in Postmenopausal Women with or without Obesity |
| title_sort | oxidative stress in postmenopausal women with or without obesity |
| topic | obesity oxidative stress menopause visceral fat lipid peroxidation oxidative damage |
| url | https://www.mdpi.com/2073-4409/12/8/1137 |
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