Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital
Introduction: Nasopharyngeal carcinoma (NPC) is a very uncommon malignant tumour in children under the age of 20. The diagnosis of paediatric NPC is challenging due to its relative rarity. This unusual occurrence is frequently linked to delayed diagnosis, which can result in advanced loco-regional...
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Student's Journal of Health Research
2023-09-01
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Series: | Student's Journal of Health Research Africa |
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Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/640 |
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author | Khushboo Shrivastava Lucky Sriwastwa Priyanka Shrivastava Tirumala Kanakadurga Sripati Rajiv Kumar Jha |
author_facet | Khushboo Shrivastava Lucky Sriwastwa Priyanka Shrivastava Tirumala Kanakadurga Sripati Rajiv Kumar Jha |
author_sort | Khushboo Shrivastava |
collection | DOAJ |
description |
Introduction: Nasopharyngeal carcinoma (NPC) is a very uncommon malignant tumour in children under the age of 20. The diagnosis of paediatric NPC is challenging due to its relative rarity. This unusual occurrence is frequently linked to delayed diagnosis, which can result in advanced loco-regional illness. Here, we investigate the clinical manifestations, investigations, and treatment of paediatric nasopharyngeal carcinoma in a nonendemic region.
Method: The data from children and adolescents who had been diagnosed with nasopharyngeal cancer served as the basis for this study, which was carried out at the Cardiology and Pathology Departments of a tertiary teaching hospital in the eastern region of India.
Result: In this retrospective analysis, 17 paediatric patients under the age of 18 were enrolled. Between December 2020 and January 2022, they were treated at a tertiary teaching hospital. 17 kids with nasopharyngeal cancer between the ages of 6 and 18 took part in this study. In this study, there were 7 girls (41.1%) and 10 boys (58.8%). NPC diagnosis occurred at a median age of 14 years (interquartile range: 6–18 years). In 15 (88.2%) individuals, neck swelling was the most frequent clinical manifestation, followed by nasal bleeding, nasal block, and hearing impairment in 10 (58.8%), 12 (70.5%), and 11 (64.7%) of cases, respectively.
Conclusion: With the exception of individuals who have distant metastatic disease, children with NPC have a very good prognosis. NPC in children is typically not clinically suspected until the patient is in a late stage. The most important prognostic factor is the TNM staging. Unfortunately, NPC frequently has distant metastases at the time of diagnosis in the paediatric age range and has a tendency to be locally progressed.
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format | Article |
id | doaj.art-e62fb622fe8a4075a0b5d26deaa379ba |
institution | Directory Open Access Journal |
issn | 2709-9997 |
language | English |
last_indexed | 2024-03-12T00:03:39Z |
publishDate | 2023-09-01 |
publisher | Student's Journal of Health Research |
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series | Student's Journal of Health Research Africa |
spelling | doaj.art-e62fb622fe8a4075a0b5d26deaa379ba2023-09-17T07:09:48ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-09-014910.51168/sjhrafrica.v4i9.640Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospitalKhushboo ShrivastavaLucky Sriwastwa0Priyanka Shrivastava1Tirumala Kanakadurga Sripati2Rajiv Kumar Jha3Department of Pathology, Nalanda Medical College and Hospital, Patna, Bihar, India.Department of Anaesthesia, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand.Department of Pathology, Nalanda Medical College and Hospital, Patna, Bihar, India.Department of Cardiology, Indira Gandhi Institute of Cardiology, Patna, Bihar, India Introduction: Nasopharyngeal carcinoma (NPC) is a very uncommon malignant tumour in children under the age of 20. The diagnosis of paediatric NPC is challenging due to its relative rarity. This unusual occurrence is frequently linked to delayed diagnosis, which can result in advanced loco-regional illness. Here, we investigate the clinical manifestations, investigations, and treatment of paediatric nasopharyngeal carcinoma in a nonendemic region. Method: The data from children and adolescents who had been diagnosed with nasopharyngeal cancer served as the basis for this study, which was carried out at the Cardiology and Pathology Departments of a tertiary teaching hospital in the eastern region of India. Result: In this retrospective analysis, 17 paediatric patients under the age of 18 were enrolled. Between December 2020 and January 2022, they were treated at a tertiary teaching hospital. 17 kids with nasopharyngeal cancer between the ages of 6 and 18 took part in this study. In this study, there were 7 girls (41.1%) and 10 boys (58.8%). NPC diagnosis occurred at a median age of 14 years (interquartile range: 6–18 years). In 15 (88.2%) individuals, neck swelling was the most frequent clinical manifestation, followed by nasal bleeding, nasal block, and hearing impairment in 10 (58.8%), 12 (70.5%), and 11 (64.7%) of cases, respectively. Conclusion: With the exception of individuals who have distant metastatic disease, children with NPC have a very good prognosis. NPC in children is typically not clinically suspected until the patient is in a late stage. The most important prognostic factor is the TNM staging. Unfortunately, NPC frequently has distant metastases at the time of diagnosis in the paediatric age range and has a tendency to be locally progressed. https://sjhresearchafrica.org/index.php/public-html/article/view/640Pediatric ageNasopharyngeal carcinomaChemoradiation |
spellingShingle | Khushboo Shrivastava Lucky Sriwastwa Priyanka Shrivastava Tirumala Kanakadurga Sripati Rajiv Kumar Jha Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital Student's Journal of Health Research Africa Pediatric age Nasopharyngeal carcinoma Chemoradiation |
title | Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital |
title_full | Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital |
title_fullStr | Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital |
title_full_unstemmed | Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital |
title_short | Paediatric non-endemic nasopharyngeal carcinoma: our experience at an Indian tertiary teaching hospital |
title_sort | paediatric non endemic nasopharyngeal carcinoma our experience at an indian tertiary teaching hospital |
topic | Pediatric age Nasopharyngeal carcinoma Chemoradiation |
url | https://sjhresearchafrica.org/index.php/public-html/article/view/640 |
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