Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

Abstract Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocytes (TILs), which is termed T cell exhaustion. This process is driven by divers...

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Bibliographic Details
Main Authors: Dian Xiong, Lu Zhang, Zhi-Jun Sun
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Military Medical Research
Subjects:
Online Access:https://doi.org/10.1186/s40779-023-00496-2

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