Toxinotype V Clostridium difficile in Humans and Food Animals
Clostridium difficile is a recognized pathogen in neonatal pigs and may contribute to enteritis in calves. Toxinotype V strains have been rare causes of human C. difficile–associated disease (CDAD). We examined toxinotype V in human disease, the genetic relationship of animal and human toxinotype V...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2008-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/14/7/07-1641_article |
| _version_ | 1819100847676588032 |
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| author | Michael A. Jhung Angela D. Thompson George E. Killgore Walter E. Zukowski Glenn Songer Michael Warny Stuart Johnson Dale N. Gerding L. Clifford McDonald Brandi M. Limbago |
| author_facet | Michael A. Jhung Angela D. Thompson George E. Killgore Walter E. Zukowski Glenn Songer Michael Warny Stuart Johnson Dale N. Gerding L. Clifford McDonald Brandi M. Limbago |
| author_sort | Michael A. Jhung |
| collection | DOAJ |
| description | Clostridium difficile is a recognized pathogen in neonatal pigs and may contribute to enteritis in calves. Toxinotype V strains have been rare causes of human C. difficile–associated disease (CDAD). We examined toxinotype V in human disease, the genetic relationship of animal and human toxinotype V strains, and in vitro toxin production of these strains. From 2001 through 2006, 8 (1.3%) of 620 patient isolates were identified as toxinotype V; before 2001, 7 (<0.02%) of ≈6,000 isolates were identified as toxinotype V. Six (46.2%) of 13 case-patients for whom information was available had community-associated CDAD. Molecular characterization showed a high degree of similarity between human and animal toxinotype V isolates; all contained a 39-bp tcdC deletion and most produced binary toxin. Further study is needed to understand the epidemiology of CDAD caused by toxinotype V C. difficile, including the potential of foodborne transmission to humans. |
| first_indexed | 2024-12-22T01:09:17Z |
| format | Article |
| id | doaj.art-e630cb84c5c74a00ab2230c702f87c4a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T01:09:17Z |
| publishDate | 2008-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e630cb84c5c74a00ab2230c702f87c4a2022-12-21T18:44:01ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-07-011471039104510.3201/eid1407.071641Toxinotype V Clostridium difficile in Humans and Food AnimalsMichael A. JhungAngela D. ThompsonGeorge E. KillgoreWalter E. ZukowskiGlenn SongerMichael WarnyStuart JohnsonDale N. GerdingL. Clifford McDonaldBrandi M. LimbagoClostridium difficile is a recognized pathogen in neonatal pigs and may contribute to enteritis in calves. Toxinotype V strains have been rare causes of human C. difficile–associated disease (CDAD). We examined toxinotype V in human disease, the genetic relationship of animal and human toxinotype V strains, and in vitro toxin production of these strains. From 2001 through 2006, 8 (1.3%) of 620 patient isolates were identified as toxinotype V; before 2001, 7 (<0.02%) of ≈6,000 isolates were identified as toxinotype V. Six (46.2%) of 13 case-patients for whom information was available had community-associated CDAD. Molecular characterization showed a high degree of similarity between human and animal toxinotype V isolates; all contained a 39-bp tcdC deletion and most produced binary toxin. Further study is needed to understand the epidemiology of CDAD caused by toxinotype V C. difficile, including the potential of foodborne transmission to humans.https://wwwnc.cdc.gov/eid/article/14/7/07-1641_articleClostridium difficileinterspecies transmissionmolecular epidemiologyresearchUnited States |
| spellingShingle | Michael A. Jhung Angela D. Thompson George E. Killgore Walter E. Zukowski Glenn Songer Michael Warny Stuart Johnson Dale N. Gerding L. Clifford McDonald Brandi M. Limbago Toxinotype V Clostridium difficile in Humans and Food Animals Emerging Infectious Diseases Clostridium difficile interspecies transmission molecular epidemiology research United States |
| title | Toxinotype V Clostridium difficile in Humans and Food Animals |
| title_full | Toxinotype V Clostridium difficile in Humans and Food Animals |
| title_fullStr | Toxinotype V Clostridium difficile in Humans and Food Animals |
| title_full_unstemmed | Toxinotype V Clostridium difficile in Humans and Food Animals |
| title_short | Toxinotype V Clostridium difficile in Humans and Food Animals |
| title_sort | toxinotype v clostridium difficile in humans and food animals |
| topic | Clostridium difficile interspecies transmission molecular epidemiology research United States |
| url | https://wwwnc.cdc.gov/eid/article/14/7/07-1641_article |
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