Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature
Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis characterized by pustules on the trunk and intertriginous areas. While oral dapsone is the first-line treatment for SPD, alternative options are necessary for patients with glucose-6-phosphate dehydrogenase deficiency, drug hyper...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/8140483 |
| _version_ | 1797216197545033728 |
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| author | Lindsey J. Wanberg Brittney Schultz Amrita Goyal |
| author_facet | Lindsey J. Wanberg Brittney Schultz Amrita Goyal |
| author_sort | Lindsey J. Wanberg |
| collection | DOAJ |
| description | Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis characterized by pustules on the trunk and intertriginous areas. While oral dapsone is the first-line treatment for SPD, alternative options are necessary for patients with glucose-6-phosphate dehydrogenase deficiency, drug hypersensitivity reactions, or refractory disease. To date, no consensus exists regarding next-best agents for SPD. In this report, we present a patient with significant SPD who developed dapsone hypersensitivity syndrome and then was successfully treated with colchicine and adalimumab. We propose that colchicine should be considered as a second-line treatment for SPD and present a therapeutic algorithm for clinicians to utilize when patients are not candidates for dapsone, have side effects requiring drug discontinuation, or have refractory disease. |
| first_indexed | 2024-04-24T11:42:08Z |
| format | Article |
| id | doaj.art-e6326afcb8cc45b1af7ccc2ccc1a7804 |
| institution | Directory Open Access Journal |
| issn | 2090-6471 |
| language | English |
| last_indexed | 2024-04-24T11:42:08Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj.art-e6326afcb8cc45b1af7ccc2ccc1a78042024-04-10T00:00:03ZengHindawi LimitedCase Reports in Dermatological Medicine2090-64712024-01-01202410.1155/2024/8140483Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the LiteratureLindsey J. Wanberg0Brittney Schultz1Amrita Goyal2University of Minnesota Medical SchoolUniversity of Minnesota Medical SchoolUniversity of Minnesota Medical SchoolSubcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis characterized by pustules on the trunk and intertriginous areas. While oral dapsone is the first-line treatment for SPD, alternative options are necessary for patients with glucose-6-phosphate dehydrogenase deficiency, drug hypersensitivity reactions, or refractory disease. To date, no consensus exists regarding next-best agents for SPD. In this report, we present a patient with significant SPD who developed dapsone hypersensitivity syndrome and then was successfully treated with colchicine and adalimumab. We propose that colchicine should be considered as a second-line treatment for SPD and present a therapeutic algorithm for clinicians to utilize when patients are not candidates for dapsone, have side effects requiring drug discontinuation, or have refractory disease.http://dx.doi.org/10.1155/2024/8140483 |
| spellingShingle | Lindsey J. Wanberg Brittney Schultz Amrita Goyal Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature Case Reports in Dermatological Medicine |
| title | Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature |
| title_full | Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature |
| title_fullStr | Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature |
| title_full_unstemmed | Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature |
| title_short | Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature |
| title_sort | treatment of subcorneal pustular dermatosis without dapsone a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2024/8140483 |
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