Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men
In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 years. They received either 858 mg of ESM (531 m...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2001-06-01
|
| Series: | Czech Journal of Food Sciences |
| Subjects: | |
| Online Access: | https://cjfs.agriculturejournals.cz/artkey/cjf-200103-0005_extract-from-silybum-marianum-as-a-nutraceutical-a-double-blind-placebo-controlled-study-in-healthy-young-men.php |
| _version_ | 1797899914139664384 |
|---|---|
| author | V. Šimánek N. Škottová J. Bartek J. Psotová P. Kosina L. Balejová J. Ulrichová |
| author_facet | V. Šimánek N. Škottová J. Bartek J. Psotová P. Kosina L. Balejová J. Ulrichová |
| author_sort | V. Šimánek |
| collection | DOAJ |
| description | In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 years. They received either 858 mg of ESM (531 mg silymarin complex calculated on pure silibinin), or placebo, daily for the period of 60 days. No side effects were found. A routine biochemical analysis of the serum was performed as a measure of lipid and liver metabolism. Positive trend towards decreased serum cholesterol level and HDL-cholesterol increase was observed in the ESM group as compared to the placebo group. The serum antioxidant capacity was significantly higher in the ESM group. The results suggest the use of ESM as a dietary supplement for hypercholesterolemia. |
| first_indexed | 2024-04-10T08:37:32Z |
| format | Article |
| id | doaj.art-e6327a70965f4ba596305f8eb9f8f0d8 |
| institution | Directory Open Access Journal |
| issn | 1212-1800 1805-9317 |
| language | English |
| last_indexed | 2024-04-10T08:37:32Z |
| publishDate | 2001-06-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Food Sciences |
| spelling | doaj.art-e6327a70965f4ba596305f8eb9f8f0d82023-02-23T03:26:31ZengCzech Academy of Agricultural SciencesCzech Journal of Food Sciences1212-18001805-93172001-06-0119310611010.17221/6585-CJFScjf-200103-0005Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young menV. Šimánek0N. Škottová1J. Bartek2J. Psotová3P. Kosina4L. Balejová5J. Ulrichová61 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁ1 LIBUE BALEJOVÁ and JITKA ULRICHOVÁIn a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 years. They received either 858 mg of ESM (531 mg silymarin complex calculated on pure silibinin), or placebo, daily for the period of 60 days. No side effects were found. A routine biochemical analysis of the serum was performed as a measure of lipid and liver metabolism. Positive trend towards decreased serum cholesterol level and HDL-cholesterol increase was observed in the ESM group as compared to the placebo group. The serum antioxidant capacity was significantly higher in the ESM group. The results suggest the use of ESM as a dietary supplement for hypercholesterolemia.https://cjfs.agriculturejournals.cz/artkey/cjf-200103-0005_extract-from-silybum-marianum-as-a-nutraceutical-a-double-blind-placebo-controlled-study-in-healthy-young-men.phpsilybum marianumsilymarin complexdouble-blindrandomised placebo-controlled studycholesterolhdlantioxidant statusnutraceutical |
| spellingShingle | V. Šimánek N. Škottová J. Bartek J. Psotová P. Kosina L. Balejová J. Ulrichová Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men Czech Journal of Food Sciences silybum marianum silymarin complex double-blind randomised placebo-controlled study cholesterol hdl antioxidant status nutraceutical |
| title | Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men |
| title_full | Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men |
| title_fullStr | Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men |
| title_full_unstemmed | Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men |
| title_short | Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men |
| title_sort | extract from silybum marianum as a nutraceutical a double blind placebo controlled study in healthy young men |
| topic | silybum marianum silymarin complex double-blind randomised placebo-controlled study cholesterol hdl antioxidant status nutraceutical |
| url | https://cjfs.agriculturejournals.cz/artkey/cjf-200103-0005_extract-from-silybum-marianum-as-a-nutraceutical-a-double-blind-placebo-controlled-study-in-healthy-young-men.php |
| work_keys_str_mv | AT vsimanek extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT nskottova extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT jbartek extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT jpsotova extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT pkosina extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT lbalejova extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen AT julrichova extractfromsilybummarianumasanutraceuticaladoubleblindplacebocontrolledstudyinhealthyyoungmen |