Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil

Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil

Cancer treatment evokes impediments to liver metabolism that culminate in fatty liver. This study determined hepatic fatty acid composition and expression of genes and mediators involved in lipid metabolism following chemotherapy treatment. Female rats bearing the Ward colon tumor were administered...

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Bibliographic Details
Main Authors: Md Monirujjaman, Leila Baghersad Renani, Peter Isesele, Abha R. Dunichand-Hoedl, Vera C. Mazurak
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy
colorectal cancer
CASSH
fatty liver
irinotecan
n-3 PUFA
Online Access:https://www.mdpi.com/1422-0067/24/4/3547

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