Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

Abstract Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven LUAD that may provide alternative th...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Springer Nature 2019-04-01
Ráidu:EMBO Molecular Medicine
Fáttát:
glutaminolysis
KRAS
lung cancer
NF1
PSAT1
Liŋkkat:https://doi.org/10.15252/emmm.201809856

Interneahtta

https://doi.org/10.15252/emmm.201809856

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