Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study
Background: Diabetic peripheral neuropathy remains asymptomatic until the late stages. Hence, a need exists for a reliable and sensitive biomarker for the early diagnosis of diabetic peripheral neuropathy. Aims and Objectives: This study aimed to evaluate serum neuron-specific enolase (NSE) relia...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-12-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/46183 |
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| author | Sangeetha Kandasamy Babu Krishnan Shivkumar Gopalakrishnan Harissh Ganesan |
| author_facet | Sangeetha Kandasamy Babu Krishnan Shivkumar Gopalakrishnan Harissh Ganesan |
| author_sort | Sangeetha Kandasamy |
| collection | DOAJ |
| description | Background: Diabetic peripheral neuropathy remains asymptomatic until the late stages. Hence, a need exists for a reliable and sensitive biomarker for the early diagnosis of diabetic peripheral neuropathy.
Aims and Objectives: This study aimed to evaluate serum neuron-specific enolase (NSE) reliability as a biomarker in diagnosing diabetic peripheral neuropathy.
Materials and Methods: In the department of biochemistry and internal medicine, a cross-sectional study was conducted at Government Villupuram Medical College from May 2018 to January 2020. One hundred diabetes patients with peripheral neuropathy were compared with 100 patients without peripheral neuropathy. A diabetic neuropathy symptom (DNS) questionnaire and diabetic neuropathy examination (DNE) score were used for diagnosis. In addition, vibration position sense and NSE values were compared between the two groups. For statistical analysis, R studio and coGuide were used.
Results: Comparisons between groups were based on age, sex, and other baseline parameters. Statistically, significance was observed between the two groups in outcome parameters such as VPB (right), VPB (left), and DNS (P<0.05). There was a weak positive correlation between NSE and DNS (rs value: 0.514, P<0.001). On the other hand, there was a strong positive correlation between NSE and DNE (rs value: 0.937, P<0.001). The NSE of 6.50 and above had a sensitivity of 53% (95%CI 42.76–63.06%) and specificity of 57% (95% CI 46.71–66.86%).
Conclusion: NSE acts as a biomarker for diabetic peripheral neuropathy. Therefore, NSE can be used for the early diagnosis of diabetic peripheral neuropathy, thereby preventing a severe form of the disease. |
| first_indexed | 2024-04-11T15:14:20Z |
| format | Article |
| id | doaj.art-e636400936f448a580a120b49b3da21e |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-11T15:14:20Z |
| publishDate | 2022-12-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-e636400936f448a580a120b49b3da21e2022-12-22T04:16:32ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-12-0113129296https://doi.org/10.3126/ajms.v13i12.46183Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional studySangeetha Kandasamy 0https://orcid.org/0000-0001-8458-512XBabu Krishnan 1https://orcid.org/0000-0003-2836-5792Shivkumar Gopalakrishnan 2https://orcid.org/0000-0002-4933-1076Harissh Ganesan 3https://orcid.org/0000-0002-3969-9352Professor, Department of Biochemistry, Government Villupuram Medical College and Hospital, Villupuram, India Associate Professor, Department of Internal Medicine, Government Villupuram Medical College and Hospital, Villupuram, India Professor, Department of Internal Medicine, Government Villupuram Medical College and Hospital, Villupuram, India MBBS, Department of Internal Medicine, Government Villupuram Medical College and Hospital, Villupuram, India Background: Diabetic peripheral neuropathy remains asymptomatic until the late stages. Hence, a need exists for a reliable and sensitive biomarker for the early diagnosis of diabetic peripheral neuropathy. Aims and Objectives: This study aimed to evaluate serum neuron-specific enolase (NSE) reliability as a biomarker in diagnosing diabetic peripheral neuropathy. Materials and Methods: In the department of biochemistry and internal medicine, a cross-sectional study was conducted at Government Villupuram Medical College from May 2018 to January 2020. One hundred diabetes patients with peripheral neuropathy were compared with 100 patients without peripheral neuropathy. A diabetic neuropathy symptom (DNS) questionnaire and diabetic neuropathy examination (DNE) score were used for diagnosis. In addition, vibration position sense and NSE values were compared between the two groups. For statistical analysis, R studio and coGuide were used. Results: Comparisons between groups were based on age, sex, and other baseline parameters. Statistically, significance was observed between the two groups in outcome parameters such as VPB (right), VPB (left), and DNS (P<0.05). There was a weak positive correlation between NSE and DNS (rs value: 0.514, P<0.001). On the other hand, there was a strong positive correlation between NSE and DNE (rs value: 0.937, P<0.001). The NSE of 6.50 and above had a sensitivity of 53% (95%CI 42.76–63.06%) and specificity of 57% (95% CI 46.71–66.86%). Conclusion: NSE acts as a biomarker for diabetic peripheral neuropathy. Therefore, NSE can be used for the early diagnosis of diabetic peripheral neuropathy, thereby preventing a severe form of the disease.https://www.nepjol.info/index.php/AJMS/article/view/46183biomarkers; diabetic neuropathy; neuron-specific enolase; peripheral nervous system diseases; type 2 diabetes mellitus |
| spellingShingle | Sangeetha Kandasamy Babu Krishnan Shivkumar Gopalakrishnan Harissh Ganesan Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study Asian Journal of Medical Sciences biomarkers; diabetic neuropathy; neuron-specific enolase; peripheral nervous system diseases; type 2 diabetes mellitus |
| title | Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study |
| title_full | Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study |
| title_fullStr | Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study |
| title_full_unstemmed | Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study |
| title_short | Serum neuron-specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy: A cross-sectional study |
| title_sort | serum neuron specific enolase as a biomarker in diagnosing diabetic peripheral neuropathy a cross sectional study |
| topic | biomarkers; diabetic neuropathy; neuron-specific enolase; peripheral nervous system diseases; type 2 diabetes mellitus |
| url | https://www.nepjol.info/index.php/AJMS/article/view/46183 |
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