Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice
In traditional Korean medicines, <i>Magnolia officinalis</i> is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of <i>Magnolia officinalis</i>. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant...
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MDPI AG
2024-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/3/339 |
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| author | Ju-Hyun Lee Dong-Soon Im |
| author_facet | Ju-Hyun Lee Dong-Soon Im |
| author_sort | Ju-Hyun Lee |
| collection | DOAJ |
| description | In traditional Korean medicines, <i>Magnolia officinalis</i> is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of <i>Magnolia officinalis</i>. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines’ (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB’s increase in CD4<sup>+</sup>RORγt<sup>+</sup> Th17 cell fraction and decrease in CD4<sup>+</sup>FoxP3<sup>+</sup> regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. |
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| language | English |
| last_indexed | 2024-04-24T18:05:21Z |
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| series | Life |
| spelling | doaj.art-e636d511b59a45a682648efd18853b902024-03-27T13:51:11ZengMDPI AGLife2075-17292024-03-0114333910.3390/life14030339Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c MiceJu-Hyun Lee0Dong-Soon Im1Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaIn traditional Korean medicines, <i>Magnolia officinalis</i> is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of <i>Magnolia officinalis</i>. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines’ (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB’s increase in CD4<sup>+</sup>RORγt<sup>+</sup> Th17 cell fraction and decrease in CD4<sup>+</sup>FoxP3<sup>+</sup> regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation.https://www.mdpi.com/2075-1729/14/3/339<i>Magnolia officinalis</i>atopymagnololdermatitismagnoliaanti-atopy |
| spellingShingle | Ju-Hyun Lee Dong-Soon Im Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice Life <i>Magnolia officinalis</i> atopy magnolol dermatitis magnolia anti-atopy |
| title | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| title_full | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| title_fullStr | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| title_full_unstemmed | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| title_short | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
| title_sort | magnolol reduces atopic dermatitis like symptoms in balb c mice |
| topic | <i>Magnolia officinalis</i> atopy magnolol dermatitis magnolia anti-atopy |
| url | https://www.mdpi.com/2075-1729/14/3/339 |
| work_keys_str_mv | AT juhyunlee magnololreducesatopicdermatitislikesymptomsinbalbcmice AT dongsoonim magnololreducesatopicdermatitislikesymptomsinbalbcmice |